Osmoregulatory actions of growth hormone and prolactin in an advanced teleost

Tatsuya Sakamoto, Brian S. Shepherd, Steffen S. Madsen, Richard S. Nishioka, Kimmakone Siharath, N. Harold Richman, Howard A. Bern, E. Gordon Grau

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124 Citations (Scopus)

Abstract

To date, growth hormone (GH) is known to contribute to seawater adaptation only in salmonid fishes (primitive Euteleostei). Accordingly, the effects of homologous GH and two forms of homologous prolactin (PRL177 and PRL188) on hypoosmoregulatory ability and gill Na+,K+-ATPase activity in a more advanced euryhaline cichlid fish, the tilapia (Oreochromis mossambicus), were examined. Following adaptation of hypophysectomized fish to 25% seawater for 3 weeks, fish were given four injections of hormone or vehicle. They were then exposed to 100% seawater for 12 hr and examined for changes in plasma osmolality. Tilapia GH (0.02 and 0.2 μg/g) significantly improved the ability of tilapia to decrease plasma osmolality following transfer to full-strength seawater, in a dose-related manner. Growth hormone treatment also significantly stimulated gill Na+,K+-ATPase activity (0.5 μg/g). Both tilapia PRLs (PRL177 and PRL188) increased plasma osmolality in 100% seawater and reduced gill Na+,K+-ATPase activity, the effects induced by PRL188 being more significant than those by PRL177. Thus, GH may be involved in seawater adaptation of tilapia, a species belonging to the most advanced teleost superorder (Acanthopterygii), whereas both PRLs in tilapia are not involved in seawater adaptation.

Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalGeneral and Comparative Endocrinology
Volume106
Issue number1
DOIs
Publication statusPublished - Apr 1997
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

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    Sakamoto, T., Shepherd, B. S., Madsen, S. S., Nishioka, R. S., Siharath, K., Richman, N. H., Bern, H. A., & Grau, E. G. (1997). Osmoregulatory actions of growth hormone and prolactin in an advanced teleost. General and Comparative Endocrinology, 106(1), 95-101. https://doi.org/10.1006/gcen.1996.6854