Osmoregulatory actions of growth hormone and its mode of action in salmonids: A review

Tatsuya Sakamoto, Stephen D. McCormick, Tetsuya Hirano

Research output: Contribution to journalArticle

190 Citations (Scopus)

Abstract

Osmoregulatory actions of growth hormone (GH) and its mode of action in salmonids are reviewed. We present evidence suggesting that insulin-like growth factor I (IGF-I) mediates some of the actions of GH on seawater acclimation. Plasma concentration and turnover of GH rise following exposure to seawater. Exogenous GH (in vivo) increases gill Na+,K+-ATPase activity and the number of gill chloride cells, and inhibits an increase in plasma osmolarity and ions following transfer of fish to seawater. A single class of high affinity GH receptors is present in the liver, gill, intestine, and kidney. The levels of IGF-I mRNA in the liver, gill and kidney increased after GH-injection. After transfer to seawater, IGF-I mRNA increased in the gill and kidney following the rise in plasma GH, although no significant change was seen in the liver. Injection of IGF-I improved the ability of the fish to maintain plasma sodium levels after transfer to seawater. GH treatment also sensitizes the interrenal to adrenocorticotropin (ACTH), increasing cortisol secretion. Both cortisol and IGF-I may be involved in mediating the action of GH in seawater adaptation, although studies on the effect of GH on osmoregulatory physiology of non-salmonid species are limited. An integrated model of the osmoregulatory actions of GH is presented, and areas in need of research are outlined.

Original languageEnglish
Pages (from-to)155-164
Number of pages10
JournalFish Physiology and Biochemistry
Volume11
Issue number1-6
DOIs
Publication statusPublished - Jul 1993
Externally publishedYes

Fingerprint

Salmonidae
somatotropin
Growth Hormone
hormone
mechanism of action
Seawater
insulin-like growth factor I
Insulin-Like Growth Factor I
seawater
gills
Liver
Plasmas
kidneys
corticotropin
Kidney
Adrenocorticotropic Hormone
Fish
liver
cortisol
Hydrocortisone

Keywords

  • cortisol
  • growth hormone
  • growth hormone receptor
  • insuline-like growth factor I
  • mode of action
  • osmoregulation
  • salmonids
  • seawater adaptation
  • thyroid hormones

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Aquatic Science

Cite this

Osmoregulatory actions of growth hormone and its mode of action in salmonids : A review. / Sakamoto, Tatsuya; McCormick, Stephen D.; Hirano, Tetsuya.

In: Fish Physiology and Biochemistry, Vol. 11, No. 1-6, 07.1993, p. 155-164.

Research output: Contribution to journalArticle

Sakamoto, Tatsuya ; McCormick, Stephen D. ; Hirano, Tetsuya. / Osmoregulatory actions of growth hormone and its mode of action in salmonids : A review. In: Fish Physiology and Biochemistry. 1993 ; Vol. 11, No. 1-6. pp. 155-164.
@article{1db42e960a89407e8738d4edf5e34138,
title = "Osmoregulatory actions of growth hormone and its mode of action in salmonids: A review",
abstract = "Osmoregulatory actions of growth hormone (GH) and its mode of action in salmonids are reviewed. We present evidence suggesting that insulin-like growth factor I (IGF-I) mediates some of the actions of GH on seawater acclimation. Plasma concentration and turnover of GH rise following exposure to seawater. Exogenous GH (in vivo) increases gill Na+,K+-ATPase activity and the number of gill chloride cells, and inhibits an increase in plasma osmolarity and ions following transfer of fish to seawater. A single class of high affinity GH receptors is present in the liver, gill, intestine, and kidney. The levels of IGF-I mRNA in the liver, gill and kidney increased after GH-injection. After transfer to seawater, IGF-I mRNA increased in the gill and kidney following the rise in plasma GH, although no significant change was seen in the liver. Injection of IGF-I improved the ability of the fish to maintain plasma sodium levels after transfer to seawater. GH treatment also sensitizes the interrenal to adrenocorticotropin (ACTH), increasing cortisol secretion. Both cortisol and IGF-I may be involved in mediating the action of GH in seawater adaptation, although studies on the effect of GH on osmoregulatory physiology of non-salmonid species are limited. An integrated model of the osmoregulatory actions of GH is presented, and areas in need of research are outlined.",
keywords = "cortisol, growth hormone, growth hormone receptor, insuline-like growth factor I, mode of action, osmoregulation, salmonids, seawater adaptation, thyroid hormones",
author = "Tatsuya Sakamoto and McCormick, {Stephen D.} and Tetsuya Hirano",
year = "1993",
month = "7",
doi = "10.1007/BF00004562",
language = "English",
volume = "11",
pages = "155--164",
journal = "Fish Physiology and Biochemistry",
issn = "0920-1742",
publisher = "Springer Netherlands",
number = "1-6",

}

TY - JOUR

T1 - Osmoregulatory actions of growth hormone and its mode of action in salmonids

T2 - A review

AU - Sakamoto, Tatsuya

AU - McCormick, Stephen D.

AU - Hirano, Tetsuya

PY - 1993/7

Y1 - 1993/7

N2 - Osmoregulatory actions of growth hormone (GH) and its mode of action in salmonids are reviewed. We present evidence suggesting that insulin-like growth factor I (IGF-I) mediates some of the actions of GH on seawater acclimation. Plasma concentration and turnover of GH rise following exposure to seawater. Exogenous GH (in vivo) increases gill Na+,K+-ATPase activity and the number of gill chloride cells, and inhibits an increase in plasma osmolarity and ions following transfer of fish to seawater. A single class of high affinity GH receptors is present in the liver, gill, intestine, and kidney. The levels of IGF-I mRNA in the liver, gill and kidney increased after GH-injection. After transfer to seawater, IGF-I mRNA increased in the gill and kidney following the rise in plasma GH, although no significant change was seen in the liver. Injection of IGF-I improved the ability of the fish to maintain plasma sodium levels after transfer to seawater. GH treatment also sensitizes the interrenal to adrenocorticotropin (ACTH), increasing cortisol secretion. Both cortisol and IGF-I may be involved in mediating the action of GH in seawater adaptation, although studies on the effect of GH on osmoregulatory physiology of non-salmonid species are limited. An integrated model of the osmoregulatory actions of GH is presented, and areas in need of research are outlined.

AB - Osmoregulatory actions of growth hormone (GH) and its mode of action in salmonids are reviewed. We present evidence suggesting that insulin-like growth factor I (IGF-I) mediates some of the actions of GH on seawater acclimation. Plasma concentration and turnover of GH rise following exposure to seawater. Exogenous GH (in vivo) increases gill Na+,K+-ATPase activity and the number of gill chloride cells, and inhibits an increase in plasma osmolarity and ions following transfer of fish to seawater. A single class of high affinity GH receptors is present in the liver, gill, intestine, and kidney. The levels of IGF-I mRNA in the liver, gill and kidney increased after GH-injection. After transfer to seawater, IGF-I mRNA increased in the gill and kidney following the rise in plasma GH, although no significant change was seen in the liver. Injection of IGF-I improved the ability of the fish to maintain plasma sodium levels after transfer to seawater. GH treatment also sensitizes the interrenal to adrenocorticotropin (ACTH), increasing cortisol secretion. Both cortisol and IGF-I may be involved in mediating the action of GH in seawater adaptation, although studies on the effect of GH on osmoregulatory physiology of non-salmonid species are limited. An integrated model of the osmoregulatory actions of GH is presented, and areas in need of research are outlined.

KW - cortisol

KW - growth hormone

KW - growth hormone receptor

KW - insuline-like growth factor I

KW - mode of action

KW - osmoregulation

KW - salmonids

KW - seawater adaptation

KW - thyroid hormones

UR - http://www.scopus.com/inward/record.url?scp=51249161772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51249161772&partnerID=8YFLogxK

U2 - 10.1007/BF00004562

DO - 10.1007/BF00004562

M3 - Article

C2 - 24202472

AN - SCOPUS:51249161772

VL - 11

SP - 155

EP - 164

JO - Fish Physiology and Biochemistry

JF - Fish Physiology and Biochemistry

SN - 0920-1742

IS - 1-6

ER -