Original: Periodontal Tissue Reaction to Mechanical Stress in Mice

Takehiro Watanabe; Norimasa Okafuji; Keisuke Nakano; Rina Muraoka; Kazuhiro Yamada; Toshiyuki Kawakami; Toshiyuki Kawakami; Takako Shimizu; Saburo Kurihara

doi:10.2485/jhtb.16.71

Original: Periodontal Tissue Reaction to Mechanical Stress in Mice

Takehiro Watanabe, Norimasa Okafuji, Keisuke Nakano, Rina Muraoka, Kazuhiro Yamada, Toshiyuki Kawakami, Toshiyuki Kawakami, Takako Shimizu, Saburo Kurihara

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

In this paper, we examined the periodontal tissue reaction course of mice to mechanical stress according to the Waldo method, before examination of the transcription factor profile change. In the examination group, the arrangement of the periodontal ligament was irregular on specimen day 1. The extension and compression sites were observed at the opposite side of the roots. In day 1 and 3 specimens, the osteoclasts appeared in the compression sites. In day 7 specimens, the number of osteoclasts was reduced in number to less than that of day 3. Immunohistochemical examination revealed that the expression patterns of Runx2 and Msx2 were clearly dynamic changed compared to the control specimens. These results suggest that the appearance of transcription factors related to cell differentiation of periodontal ligament, which was due to the mechanical stress of insertion of elastic separator, happened within 24 hours.

Original language	English
Pages (from-to)	71-74
Number of pages	4
Journal	Journal of Hard Tissue Biology
Volume	16
Issue number	2
DOIs	https://doi.org/10.2485/jhtb.16.71
Publication status	Published - Jan 2007
Externally published	Yes

Keywords

Mechanical stress
Osteoblasts
Osteoclasts
Periodontal ligament
Tissue reaction

ASJC Scopus subject areas

Medicine (miscellaneous)
Biochemistry
Biomaterials
Orthopedics and Sports Medicine
Dentistry(all)
Cell Biology

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Original : Periodontal Tissue Reaction to Mechanical Stress in Mice. / Watanabe, Takehiro; Okafuji, Norimasa; Nakano, Keisuke; Muraoka, Rina; Yamada, Kazuhiro; Kawakami, Toshiyuki; Kawakami, Toshiyuki; Shimizu, Takako; Kurihara, Saburo.

In: Journal of Hard Tissue Biology, Vol. 16, No. 2, 01.2007, p. 71-74.

Research output: Contribution to journal › Article › peer-review

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AU - Kawakami, Toshiyuki

AU - Shimizu, Takako

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