Organic redox cascade cyclization of 2-alkynylquinones by ascorbic acid in combination with a copper catalyst and its application to formal synthesis of liphagal

Taejoo Jeong, Yusuke Okanishi, Sora Yotsui, In Su Kim, Takehiko Yoshimitsu

Research output: Contribution to journalArticlepeer-review

Abstract

A stoichiometric amount of ascorbic acid in combination with CuCl2·2H2O catalyst was found to promote the organic redox cascade transformation of alkynylquinones, successfully furnishing hydroxybenzofuran derivatives. By applying the present organic redox-driven copper-catalyzed cyclization protocol, a formal synthetic route to liphagal has been developed.

Original languageEnglish
JournalNew Journal of Chemistry
DOIs
Publication statusAccepted/In press - 2023

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Materials Chemistry

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