Oral surgery in patients with antiphospholipid syndrome

Kohei Okuyama, Tomofumi Naruse, Hirokazu Yutori, Souichi Yanamoto, Masahiro Umeda

Research output: Contribution to journalArticlepeer-review


Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent thrombosis, other associated autoimmune disease, and/or obstetrical morbidity along with persistent production of antiphospholipid antibodies. Because of the nature of this systemic disease, most patients are medicated with antithrombotic agents and abundant glucocorticoids. This study reports a cohort of 16 patients with APS, who underwent oral surgery between 2010 and 2017 at the Nagasaki University Hospital. Because oral antithrombotic therapy was continued in the perioperative period, all wounds were strictly closed by suturing to prevent postoperative bleeding. Perioperative laboratory dates and medications were assessed. All patients achieved local postoperative hemostasis and did not exhibit systemic complications. Moreover, there were no postoperative systemic and/or local infections. Oral surgeons should suture oral wounds and ensure local hemostasis to prevent postoperative bleeding. Because patients with APS are likely to develop thrombosis despite continued administration of antithrombotic medications, strict perioperative examination of blood coagulation is needed. Furthermore, it is important to consider the damage and stress caused due to oral surgery. Moreover, when necessary, glucocorticoid therapy should be carefully administered, in accordance with the degree of invasion and judgment of the attending physician.

Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalJournal of Oral Science
Issue number3
Publication statusPublished - Sep 2019
Externally publishedYes


  • Antiphospholipid syndrome
  • Antithrombotic medication
  • Collagen disease
  • Glucocorticoid
  • Oral surgery
  • Postoperative local hemostasis

ASJC Scopus subject areas

  • Dentistry(all)


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