Oral midazolam for sedation in minor oral operations in children: A retrospective study

Atsushi Kohjitani, Hitoshi Higuchi, Masahiko Shimada, Takuya Miyawaki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Our aim was to find out the optimal dose of oral midazolam to sedate children according to age. Thirty-five patients aged 10 or under who had minor oral operations under sedation with midazolam were enrolled. Correlations between age (X) and dose of midazolam (mg/kg; Y) were analysed by Pearson's correlation coefficient, and relations were fitted by simple regression. Doses of midazolam were significantly reduced as age increased (Y = 0.969 - 0.04X; R = 0.48) in the satisfactory group (n = 25), whereas those in the overdose group (n = 10) (patients who vomited, became agitated, or took some time to come round) were significantly higher, decreased with age, and showed a better correlation coefficient (Y = 1.375 - 0.65X; R = 0.78). These findings suggest that both the requirement and threshold of midazolam decreases with age.

Original languageEnglish
Pages (from-to)330-331
Number of pages2
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume46
Issue number4
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Children
  • Midazolam
  • Nitrous oxide
  • Oral sedation
  • Outpatient

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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