Oral manifestations of cyclic neutropenia in a Japanese child: Case report with a 5-year follow-up

Yukie Nakai, Chikako Ishihara, Sagiri Ogata, Tsutomu Shimono

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cyclic neutropenia is an uncommon hematologic disorder characterized by a marked decrease in the number of neutrophils in the peripheral blood occurring at regular intervals. The neutropenic phase is characteristically associated with clinical symptoms such as recurrent fever, malaise, headaches, anorexia, pharyngitis, ulcers of the oral mucous membrane, and gingival inflammation. This case report describes a Japanese girl who has this disease and suffers from periodontitis and oral ulceration. Her case has been followed up for the past 5 years from age 7 to 12. The importance of regular oral hygiene, careful removal of subgingival plaque and calculus, and periodic and thorough professional mechanical tooth cleaning was emphasized to arrest the progress of periodontal breakdown. Local antibiotic application with minocycline ointment in periodontal pockets was beneficial as an ancillary treatment, especially during neutropenic periods.

Original languageEnglish
Pages (from-to)383-388
Number of pages6
JournalPediatric Dentistry
Volume25
Issue number4
Publication statusPublished - 2003
Externally publishedYes

Keywords

  • Cyclic neutropenia
  • Mixed dentition
  • Periodontitis

ASJC Scopus subject areas

  • Dentistry(all)

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    Nakai, Y., Ishihara, C., Ogata, S., & Shimono, T. (2003). Oral manifestations of cyclic neutropenia in a Japanese child: Case report with a 5-year follow-up. Pediatric Dentistry, 25(4), 383-388.