Oral gabapentin (neurontin) treatment of refractory genitourinary tract pain

K. Sasaki, C. P. Smith, Y. C. Chuang, You Lee Ji You Lee, Chul Kim Joon Chul Kim, M. B. Chancellor

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Purpose: Refractory genitourinary pain is a common but difficult condition to treat. Examples of chronic genitourinary pain include orchalgia, interstitial cystitis, pain after bladder suspension surgery, nonbacterial prostatitis, and genital pain related to lumbosacral neuropathy. We report our experience with oral gabapentin treatment for this condition. Gabapentin is an anticonvulsant with unclear but therapeutic effects on neurologic pain. Materials and Methods: Twenty-one patients referred with refractory genitourinary pain were treated with oral gabapentin. There were 9 men and 12 women. In the male patients, the location of pain was testicle (4), bladder (2), penis (1), or prostate (2). In female patients, the pain was located in the urethra (4), bladder (6), vulva (1), or vagina (1). The dose of gabapentin was titrated from 300 up to 2,100 mg/day. Subjective pain severity and 10-cm visual pain scale was used before and 6 months after therapy. Results: The mean dose of gabapentin was 1,200 mg/day (range 300-2,100 mg). Ten of 21 patients reported subjective improvement of their pain. The remaining patients did not perceive any improvement. Gabapentin was well tolerated; only 4 patients dropped out due to side effects. The most common adverse effects were dizziness and drowsiness. Five of 8 patients with interstitial cystitis reported improvement. Conclusions: Although only 10 of 21 patients improved with gabapentin, this cohort included only patients with refractory genitourinary pain that failed a wide range of prior treatments. Gabapentin belongs in the armaterium of the urologist who treats genitourinary pain.

Original languageEnglish
Pages (from-to)47-49
Number of pages3
JournalTechniques in Urology
Volume7
Issue number1
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Pain
Intractable Pain
Interstitial Cystitis
Urinary Bladder
Therapeutics
gabapentin
Prostatitis
Vulva
Sleep Stages
Penis
Dizziness
Vagina
Therapeutic Uses
Urethra
Chronic Pain
Anticonvulsants
Nervous System
Testis
Prostate
Suspensions

Keywords

  • Bladder
  • Gabapentin
  • Interstitial cystitis
  • Pain
  • Prostate

ASJC Scopus subject areas

  • Urology

Cite this

Sasaki, K., Smith, C. P., Chuang, Y. C., Ji You Lee, Y. L., Joon Chul Kim, C. K., & Chancellor, M. B. (2001). Oral gabapentin (neurontin) treatment of refractory genitourinary tract pain. Techniques in Urology, 7(1), 47-49.

Oral gabapentin (neurontin) treatment of refractory genitourinary tract pain. / Sasaki, K.; Smith, C. P.; Chuang, Y. C.; Ji You Lee, You Lee; Joon Chul Kim, Chul Kim; Chancellor, M. B.

In: Techniques in Urology, Vol. 7, No. 1, 2001, p. 47-49.

Research output: Contribution to journalArticle

Sasaki, K, Smith, CP, Chuang, YC, Ji You Lee, YL, Joon Chul Kim, CK & Chancellor, MB 2001, 'Oral gabapentin (neurontin) treatment of refractory genitourinary tract pain', Techniques in Urology, vol. 7, no. 1, pp. 47-49.
Sasaki K, Smith CP, Chuang YC, Ji You Lee YL, Joon Chul Kim CK, Chancellor MB. Oral gabapentin (neurontin) treatment of refractory genitourinary tract pain. Techniques in Urology. 2001;7(1):47-49.
Sasaki, K. ; Smith, C. P. ; Chuang, Y. C. ; Ji You Lee, You Lee ; Joon Chul Kim, Chul Kim ; Chancellor, M. B. / Oral gabapentin (neurontin) treatment of refractory genitourinary tract pain. In: Techniques in Urology. 2001 ; Vol. 7, No. 1. pp. 47-49.
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