Oral faecal microbiota transplantation for the treatment of Clostridium difficile-associated diarrhoea in a dog: A case report

Koji Sugita, Nanako Yanuma, Hikaru Ohno, Kaho Takahashi, Koji Kawano, Hidetoshi Morita, Keitaro Ohmori

Research output: Contribution to journalArticle

Abstract

Background: Successful clinical outcomes of faecal microbiota transplantation (FMT) for recurrent Clostridium difficile infection have been reported in humans and a marmoset. However, it has been unclear whether oral FMT was effective for the treatment of C. difficile-associated diarrhoea in dogs. Case presentation: An 8-month-old, intact male French bulldog was presented with a 4-month history of intermittent large bowel diarrhoea. Physical and clinical examinations did not identify any specific causes for diarrhoea. Real-time PCR analysis and immunochromatography detected C. difficile antigen and toxin A&B genes and proteins in a faecal sample. Based on these findings, diarrhoea in the dog was considered to be induced by C. difficile-associated colitis. The dog was treated with oral FMT, in which a faecal solution obtained from a healthy beagle was orally administered to the subject. Stool consistency and frequency and faecal blood and mucus became normal 2-3 days after oral FMT, and real-time PCR analysis and immunochromatography was negative for C. difficile antigen and toxin A&B genes and proteins. No adverse events were observed. Conclusion: The present case report demonstrated that oral FMT was an effective treatment for C. difficile-associated diarrhoea in a dog. The findings in this report provide a rationale to evaluate clinical efficacy of oral FMT for other gastrointestinal diseases in dogs.

Original languageEnglish
Article number11
JournalBMC Veterinary Research
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 7 2019

    Fingerprint

Keywords

  • Clostridium difficile
  • Diarrhoea
  • Dog
  • Oral faecal microbiota transplantation

ASJC Scopus subject areas

  • veterinary(all)

Cite this