Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment

Isao Watanabe, Nagato Kuriyama, Fumitaro Miyatani, Ryota Nomura, Shuhei Naka, Kazuhiko Nakano, Masafumi Ihara, Komei Iwai, Daisuke Matsui, Etsuko Ozaki, Teruhide Koyama, Masaru Nishigaki, Toshiro Yamamoto, Aiko Tamura, Toshiki Mizuno, Kentaro Akazawa, Akihiro Takada, Kazuo Takeda, Kei Yamada, Masanori NakagawaTokutaro Tanaka, Narisato Kanamura, Robert P. Friedland, Yoshiyuki Watanabe

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Abstract

Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on cnm-positive Streptococcus mutans is involved in the development of CMBs. However, whether the collagen binding activity of cnm-positive S. mutans is related to the nature of the CMBs or to cognitive impairment is unclear. Two-hundred seventy nine community residents (70.0 years) were examined for the presence or absence of cnm-positive S. mutans in the saliva by PCR and collagen binding activity, CMBs, and cognitive function were evaluated. Cnm-positive S. mutans was detected more often among subjects with CMBs (p < 0.01) than those without. The risk of CMBs was significantly higher (odds ratio = 14.3) in the group with S. mutans expressing collagen binding activity, as compared to the group without that finding. Deep CMBs were more frequent (67%) and cognitive function was lower among subjects with cnm-positive S. mutans expressing collagen binding activity. This work supports the role of oral health in stroke and dementia and proposes a molecular mechanism for the interaction.

Original languageEnglish
Article number38561
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - Dec 9 2016
Externally publishedYes

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ASJC Scopus subject areas

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Cite this

Watanabe, I., Kuriyama, N., Miyatani, F., Nomura, R., Naka, S., Nakano, K., Ihara, M., Iwai, K., Matsui, D., Ozaki, E., Koyama, T., Nishigaki, M., Yamamoto, T., Tamura, A., Mizuno, T., Akazawa, K., Takada, A., Takeda, K., Yamada, K., ... Watanabe, Y. (2016). Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment. Scientific Reports, 6, [38561]. https://doi.org/10.1038/srep38561