Abstract
Previously we reported haematopoietic death as an effect of tritiated water (HTO) in drinking water in the concentration range from 5.92 × 1011 to 1.85 × 1010 Bq/dm3. In the present study the effects of HTO in a lower concentration range from 9.25 × 109 Bq/dm3 (0.240 Gy/day) to 3.70 × 108 Bq/dm3 (0.096 Gy/day) are reported. Female (C57BL/6N and C3H/He)F1 mice were maintained on drinking water containing various levels of HTO. Mice survived for > 150 days with a high incidence of tumour development (70 to 80%). In the dose-rate range from 9.25 × 109 Bq/dm3 (0.240 Gy/day) to 1.85 × 109 Bq/dm3 (0.048 Gy/day) the main cause of death was thymic lymphoma. However, at a dose-rate of 9.25 × 108 Bq/dm3 (0.024 Gy/day) the incidence of thymic lymphoma sharply decreased, while the incidence of other tumours increased. The tumour types became more diverse at lower concentrations of HTO. The latent period of tumour development was shorter and the life-shortening effect was more marked by 3H βirradiation in this study than by X- or γirradiation reported in other investigations.
| Original language | English |
|---|---|
| Pages (from-to) | 47-54 |
| Number of pages | 8 |
| Journal | International Journal of Radiation Biology |
| Volume | 68 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging
Cite this
Oral administration of tritiated water (HTO) in mouse. II. Tumour development. / Yamamoto, O.; Seyama, T.; Jo, T.; Terato, Hiroaki; Saito, T.; Kinomura, A.
In: International Journal of Radiation Biology, Vol. 68, No. 1, 01.01.1995, p. 47-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral administration of tritiated water (HTO) in mouse. II. Tumour development
AU - Yamamoto, O.
AU - Seyama, T.
AU - Jo, T.
AU - Terato, Hiroaki
AU - Saito, T.
AU - Kinomura, A.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Previously we reported haematopoietic death as an effect of tritiated water (HTO) in drinking water in the concentration range from 5.92 × 1011 to 1.85 × 1010 Bq/dm3. In the present study the effects of HTO in a lower concentration range from 9.25 × 109 Bq/dm3 (0.240 Gy/day) to 3.70 × 108 Bq/dm3 (0.096 Gy/day) are reported. Female (C57BL/6N and C3H/He)F1 mice were maintained on drinking water containing various levels of HTO. Mice survived for > 150 days with a high incidence of tumour development (70 to 80%). In the dose-rate range from 9.25 × 109 Bq/dm3 (0.240 Gy/day) to 1.85 × 109 Bq/dm3 (0.048 Gy/day) the main cause of death was thymic lymphoma. However, at a dose-rate of 9.25 × 108 Bq/dm3 (0.024 Gy/day) the incidence of thymic lymphoma sharply decreased, while the incidence of other tumours increased. The tumour types became more diverse at lower concentrations of HTO. The latent period of tumour development was shorter and the life-shortening effect was more marked by 3H βirradiation in this study than by X- or γirradiation reported in other investigations.
AB - Previously we reported haematopoietic death as an effect of tritiated water (HTO) in drinking water in the concentration range from 5.92 × 1011 to 1.85 × 1010 Bq/dm3. In the present study the effects of HTO in a lower concentration range from 9.25 × 109 Bq/dm3 (0.240 Gy/day) to 3.70 × 108 Bq/dm3 (0.096 Gy/day) are reported. Female (C57BL/6N and C3H/He)F1 mice were maintained on drinking water containing various levels of HTO. Mice survived for > 150 days with a high incidence of tumour development (70 to 80%). In the dose-rate range from 9.25 × 109 Bq/dm3 (0.240 Gy/day) to 1.85 × 109 Bq/dm3 (0.048 Gy/day) the main cause of death was thymic lymphoma. However, at a dose-rate of 9.25 × 108 Bq/dm3 (0.024 Gy/day) the incidence of thymic lymphoma sharply decreased, while the incidence of other tumours increased. The tumour types became more diverse at lower concentrations of HTO. The latent period of tumour development was shorter and the life-shortening effect was more marked by 3H βirradiation in this study than by X- or γirradiation reported in other investigations.
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U2 - 10.1080/09553009514550911
DO - 10.1080/09553009514550911
M3 - Article
VL - 68
SP - 47
EP - 54
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
SN - 0955-3002
IS - 1
ER -