TY - JOUR
T1 - Oral administration of tritiated water (HTO) in mouse. II. Tumour development
AU - Yamamoto, O.
AU - Seyama, T.
AU - Jo, T.
AU - Terato, H.
AU - Saito, T.
AU - Kinomura, A.
N1 - Funding Information:
This research was supported by grants-in-aid for Scientific Research (nos 63050028, 63055019 and 02559012) from the Ministry of Education, Science and Culture, Japan . We thank Mr S . Takeoka, Mr S . Suga, Mr K. Kitagawa and Miss N. Maeda for their maintenance of the HTO experimental facilities and Mr T . Nishioka for his preparation of thin histological sections .
PY - 1995
Y1 - 1995
N2 - Previously we reported haematopoietic death as an effect of tritiated water (HTO) in drinking water in the concentration range from 5.92 × 1011 to 1.85 × 1010 Bq/dm3. In the present study the effects of HTO in a lower concentration range from 9.25 × 109 Bq/dm3 (0.240 Gy/day) to 3.70 × 108 Bq/dm3 (0.096 Gy/day) are reported. Female (C57BL/6N and C3H/He)F1 mice were maintained on drinking water containing various levels of HTO. Mice survived for > 150 days with a high incidence of tumour development (70 to 80%). In the dose-rate range from 9.25 × 109 Bq/dm3 (0.240 Gy/day) to 1.85 × 109 Bq/dm3 (0.048 Gy/day) the main cause of death was thymic lymphoma. However, at a dose-rate of 9.25 × 108 Bq/dm3 (0.024 Gy/day) the incidence of thymic lymphoma sharply decreased, while the incidence of other tumours increased. The tumour types became more diverse at lower concentrations of HTO. The latent period of tumour development was shorter and the life-shortening effect was more marked by 3H βirradiation in this study than by X- or γirradiation reported in other investigations.
AB - Previously we reported haematopoietic death as an effect of tritiated water (HTO) in drinking water in the concentration range from 5.92 × 1011 to 1.85 × 1010 Bq/dm3. In the present study the effects of HTO in a lower concentration range from 9.25 × 109 Bq/dm3 (0.240 Gy/day) to 3.70 × 108 Bq/dm3 (0.096 Gy/day) are reported. Female (C57BL/6N and C3H/He)F1 mice were maintained on drinking water containing various levels of HTO. Mice survived for > 150 days with a high incidence of tumour development (70 to 80%). In the dose-rate range from 9.25 × 109 Bq/dm3 (0.240 Gy/day) to 1.85 × 109 Bq/dm3 (0.048 Gy/day) the main cause of death was thymic lymphoma. However, at a dose-rate of 9.25 × 108 Bq/dm3 (0.024 Gy/day) the incidence of thymic lymphoma sharply decreased, while the incidence of other tumours increased. The tumour types became more diverse at lower concentrations of HTO. The latent period of tumour development was shorter and the life-shortening effect was more marked by 3H βirradiation in this study than by X- or γirradiation reported in other investigations.
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U2 - 10.1080/09553009514550911
DO - 10.1080/09553009514550911
M3 - Article
C2 - 7629437
AN - SCOPUS:0029080034
VL - 68
SP - 47
EP - 54
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
SN - 0955-3002
IS - 1
ER -