Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses

Miho Tamaki, Toshihiko Matsuo

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To find optical coherence tomographic parameters related with visual acuity, and, thus, which might be used as objective signs to predict visual acuity after future treatment, for example retinal prosthesis implantation, 86 eyes of 45 consecutive patients with retinitis pigmentosa, who showed no macular diseases, underwent optical coherence tomography to measure macular retinal thickness and peripapillary retinal nerve fiber layer (RNFL) thickness, and to obtain horizontal cross-sectional images at the fovea for observation of the inner segment/outer segment (IS/OS) junction line. Best-corrected visual acuity was significantly better either in the right eyes or in the left eyes with greater retinal thickness of all four quadrants of the macular area in the inner ring, encompassing 1-3 mm from the foveal center (P\0.05, Spearman rank correlation test), and also with the presence of the IS/OS line at the fovea (P\0.0001, Wilcoxon-Kruskal-Wallis rank sum test). Retinal average thickness in the posterior pole covering the 6 9 6 mm square area was positively correlated with peripapillary RNFLaverage thickness either in the right eyes or in the left eyes (P\0.05). The average thickness of the peripapillary RNFLbecame significantly less with age (P\0.05), but was not related with visual acuity. Macular retinal thickness and the presence of the IS/OS line, but not peripapillary RNFLthickness, could serve as objective signs for better visual acuity in retinitis pigmentosa. The macular retinal thickness might be used as an objective predictor to choose patients with retinitis pigmentosa who would be expected to gain vision after retinal prosthesis implantation.

Original languageEnglish
Pages (from-to)140-150
Number of pages11
JournalJournal of Artificial Organs
Volume14
Issue number2
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Visual Prosthesis
Retinitis Pigmentosa
Prosthetics
Visual Acuity
Prosthesis Implantation
Optical tomography
Poles
Fibers
Optical Coherence Tomography
Nonparametric Statistics
Nerve Fibers
Observation
Prostheses and Implants

Keywords

  • Inner segment/outer segment (IS/OS) line
  • Macular retinal thickness
  • Optical coherence tomography
  • Peripapillary retinal nerve fiber layer thickness
  • Retinal prosthesis
  • Retinitis pigmentosa

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine
  • Medicine (miscellaneous)
  • Medicine(all)

Cite this

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title = "Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses",
abstract = "To find optical coherence tomographic parameters related with visual acuity, and, thus, which might be used as objective signs to predict visual acuity after future treatment, for example retinal prosthesis implantation, 86 eyes of 45 consecutive patients with retinitis pigmentosa, who showed no macular diseases, underwent optical coherence tomography to measure macular retinal thickness and peripapillary retinal nerve fiber layer (RNFL) thickness, and to obtain horizontal cross-sectional images at the fovea for observation of the inner segment/outer segment (IS/OS) junction line. Best-corrected visual acuity was significantly better either in the right eyes or in the left eyes with greater retinal thickness of all four quadrants of the macular area in the inner ring, encompassing 1-3 mm from the foveal center (P\0.05, Spearman rank correlation test), and also with the presence of the IS/OS line at the fovea (P\0.0001, Wilcoxon-Kruskal-Wallis rank sum test). Retinal average thickness in the posterior pole covering the 6 9 6 mm square area was positively correlated with peripapillary RNFLaverage thickness either in the right eyes or in the left eyes (P\0.05). The average thickness of the peripapillary RNFLbecame significantly less with age (P\0.05), but was not related with visual acuity. Macular retinal thickness and the presence of the IS/OS line, but not peripapillary RNFLthickness, could serve as objective signs for better visual acuity in retinitis pigmentosa. The macular retinal thickness might be used as an objective predictor to choose patients with retinitis pigmentosa who would be expected to gain vision after retinal prosthesis implantation.",
keywords = "Inner segment/outer segment (IS/OS) line, Macular retinal thickness, Optical coherence tomography, Peripapillary retinal nerve fiber layer thickness, Retinal prosthesis, Retinitis pigmentosa",
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