Opposite effects of rough and gentle handling with repeated saline administration on c-fos mRNA expression in the rat brain

M. Asanuma, N. Ogawa, H. Hirata, H. Chou, K. Tanaka, A. Mori

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The rough handling with repeated saline administration (1.2 ml/kg s.c. for 7 days) enhanced cortical c -fos mRNA expression in the rat brain after a single saline stimulation (1.2 ml/kg s.c.) due to increasing baseline c -fos mRNA levels, whereas the gentle handling with repeated saline administration declined c -fos mRNA expression after a single injection due to decreasing the baseline of c -fos mRNA levels. These two types of handling with the repeated injection led to diametrically opposite results on c-fos mRNA expression after a single stimulation. Neither two types of handling with repeated saline injections affected the net increment of c-fos mRNA induction after a single stimulation, therefore, the effects of handling with repeated treatment on c-fos mRNA expression might be independent of the effects of a single saline stimulation. The present study suggests that c-fos mRNA induction after a single stimulation might be affected by the types or intensities of handling and that care must be taken to estimate c-fos mRNA induction.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalJournal of Neural Transmission
Volume90
Issue number3
DOIs
Publication statusPublished - Oct 1 1992

Keywords

  • c-fos
  • frontal cortex
  • handling
  • messenger RNA
  • rat brain
  • repeated administration
  • saline
  • striatum

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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