Opposing pharmacological actions of cepharanthin on lipopolysaccharide-induced histidine decarboxylase activity in mice spleens

Norio Sogawa, Chiharu Aoki Sogawa, Eiko Iwata Abuku, Tetsuyoshi Inoue, Nariaki Oda, Kanji Kishi, Hiroaki Furuta

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A biscoclaurin alkaloid preparation, cepharanthin (Ceph), is reported to have opposing pharmacological effects, enhancement or depression, on several cells and tissues, although detailed mechanisms remain unclear. Previously, we reported that Ceph enhanced lipopolysaccharide (LPS)-induced histidine decarboxylase (HDC) activity in mice spleens by consecutive pre-administration. In this study, we examined the pharmacological effects on HDC activity of a single Ceph pre-administration to test the influence of the administration method. Consequently, HDC activities were decreased by a single administration 15 minutes before LPS challenge in ddY and ICR mice spleens. Moreover, to further examine this suppressing effect, we employed genetically mast cell-deficient WBB6F1 W/Wv (W/Wv) mice to avoid the influence of mast cells. In W/Wv mice, HDC activity was enhanced, but not in the congenic WBB6F1 +/+ mice. These findings suggest that mast cells influence the depressant effect on HDC activity by a Ceph single administration in mast cell sufficient mice.

Original languageEnglish
Pages (from-to)1395-1403
Number of pages9
JournalLife Sciences
Volume68
Issue number12
DOIs
Publication statusPublished - Feb 9 2001

Keywords

  • Cepharanthin
  • Histidine decarboxylase
  • Lipopolysaccharide
  • Mast cell-deficient

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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