Open-loop dynamic and static characteristics of the carotid sinus baroreflex in rats with chronic heart failure after myocardial infarction

Toru Kawada, Meihua Li, Atsunori Kamiya, Shuji Shimizu, Kazunori Uemura, Hiromi Yamamoto, Masaru Sugimachi

Research output: Contribution to journalArticle

37 Citations (Scopus)


We estimated open-loop dynamic characteristics of the carotid sinus baroreflex in normal control rats and chronic heart failure (CHF) rats after myocardial infarction. First, the neural arc transfer function from carotid sinus pressure to splanchnic sympathetic nerve activity (SNA) and its corresponding step response were examined. Although the steady-state response was attenuated in CHF, the negative peak response and the time to peak did not change significantly, suggesting preserved neural arc dynamic characteristics. Next, the peripheral arc transfer function from SNA to arterial pressure (AP) and its corresponding step response were examined. The steady-state response and the initial slope were reduced in CHF, suggesting impaired end-organ responses. In a simulation study based on the dynamic and static characteristics, the percent recovery of AP was reduced progressively as the size of disturbance increased in CHF, suggesting that a reserve for AP buffering is lost in CHF despite relatively maintained baseline AP.

Original languageEnglish
Pages (from-to)283-298
Number of pages16
JournalJournal of Physiological Sciences
Issue number4
Publication statusPublished - Jul 1 2010
Externally publishedYes



  • Arterial pressure
  • Equilibrium diagram
  • Sympathetic nerve activity
  • Systems analysis
  • Transfer function
  • White noise

ASJC Scopus subject areas

  • Physiology
  • Medicine(all)

Cite this