One-pot multistep synthesis of 4-acetoxy-2-amino-3-arylbenzofurans from 1-aryl-2-nitroethylenes and cyclohexane-1,3-diones

Teruhiko Ishikawa, Tadashi Miyahara, Mami Asakura, Shuichi Higuchi, Yayoi Miyauchi, Seiki Saito

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

(Chemical Equation Presented) A novel method for synthesizing 4-acetoxy-2-amino-3-arylbenzofurans (4) from 1-aryl-2-nitroethylenes (1) and cyclohexane-1,3-diones (2) is described. The method features one-pot operation of a solution of 1 and 2 in THF with catalytic Et3N (rt, 12 h) followed with Ac2O, Et3N, and DMAP (rt, 5 h), although the process consists of 13 elementary reactions.

Original languageEnglish
Pages (from-to)1211-1214
Number of pages4
JournalOrganic Letters
Volume7
Issue number7
DOIs
Publication statusPublished - Mar 31 2005

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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