One-pot multistep synthesis of 4-acetoxy-2-amino-3-arylbenzofurans from 1-aryl-2-nitroethylenes and cyclohexane-1,3-diones

Teruhiko Ishikawa, Tadashi Miyahara, Mami Asakura, Shuichi Higuchi, Yayoi Miyauchi, Seiki Saito

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

(Chemical Equation Presented) A novel method for synthesizing 4-acetoxy-2-amino-3-arylbenzofurans (4) from 1-aryl-2-nitroethylenes (1) and cyclohexane-1,3-diones (2) is described. The method features one-pot operation of a solution of 1 and 2 in THF with catalytic Et3N (rt, 12 h) followed with Ac2O, Et3N, and DMAP (rt, 5 h), although the process consists of 13 elementary reactions.

Original languageEnglish
Pages (from-to)1211-1214
Number of pages4
JournalOrganic Letters
Volume7
Issue number7
DOIs
Publication statusPublished - Mar 31 2005

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Dione
cyclohexane
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  • Molecular Medicine

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One-pot multistep synthesis of 4-acetoxy-2-amino-3-arylbenzofurans from 1-aryl-2-nitroethylenes and cyclohexane-1,3-diones. / Ishikawa, Teruhiko; Miyahara, Tadashi; Asakura, Mami; Higuchi, Shuichi; Miyauchi, Yayoi; Saito, Seiki.

In: Organic Letters, Vol. 7, No. 7, 31.03.2005, p. 1211-1214.

Research output: Contribution to journalArticle

Ishikawa, Teruhiko ; Miyahara, Tadashi ; Asakura, Mami ; Higuchi, Shuichi ; Miyauchi, Yayoi ; Saito, Seiki. / One-pot multistep synthesis of 4-acetoxy-2-amino-3-arylbenzofurans from 1-aryl-2-nitroethylenes and cyclohexane-1,3-diones. In: Organic Letters. 2005 ; Vol. 7, No. 7. pp. 1211-1214.
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AU - Miyauchi, Yayoi

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