Oncostatin M synergistically inhibits HCV RNA replication in combination with interferon-α

Masanori Ikeda, Kyoko Mori, Yasuo Ariumi, Hiromichi Dansako, Nobuyuki Kato

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Oncostatin M (OSM), a member of the interleukin-6 family, possesses various functions, including hepatocyte differentiation and suppression of melanoma cell growth. Here, we report anti-hepatitis C virus (HCV) activity of OSM as a new function of this cytokine. OSM possessed marked anti-HCV activity (50% effective concentration: 0.71 ng/ml) in an HCV RNA replication cell culture system. The most striking finding is that OSM exhibited synergistic inhibitory activity on interferon (IFN)-α even at a low concentration with weak anti-HCV activity, such as 25 pg/ml. OSM is a candidate anti-HCV reagent and may improve the current IFN therapy for patients with chronic hepatitis C.

Original languageEnglish
Pages (from-to)1434-1438
Number of pages5
JournalFEBS Letters
Volume583
Issue number9
DOIs
Publication statusPublished - May 6 2009

Keywords

  • Hepatitis C virus
  • Interferon
  • Oncostatin M

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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