Oncostatin M synergistically inhibits HCV RNA replication in combination with interferon-α

Masanori Ikeda; Kyoko Mori; Yasuo Ariumi; Hiromichi Dansako; Nobuyuki Kato

doi:10.1016/j.febslet.2009.03.054

Oncostatin M synergistically inhibits HCV RNA replication in combination with interferon-α

Masanori Ikeda, Kyoko Mori, Yasuo Ariumi, Hiromichi Dansako, Nobuyuki Kato

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Oncostatin M (OSM), a member of the interleukin-6 family, possesses various functions, including hepatocyte differentiation and suppression of melanoma cell growth. Here, we report anti-hepatitis C virus (HCV) activity of OSM as a new function of this cytokine. OSM possessed marked anti-HCV activity (50% effective concentration: 0.71 ng/ml) in an HCV RNA replication cell culture system. The most striking finding is that OSM exhibited synergistic inhibitory activity on interferon (IFN)-α even at a low concentration with weak anti-HCV activity, such as 25 pg/ml. OSM is a candidate anti-HCV reagent and may improve the current IFN therapy for patients with chronic hepatitis C.

Original language	English
Pages (from-to)	1434-1438
Number of pages	5
Journal	FEBS Letters
Volume	583
Issue number	9
DOIs	https://doi.org/10.1016/j.febslet.2009.03.054
Publication status	Published - May 6 2009

Keywords

Hepatitis C virus
Interferon
Oncostatin M

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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title = "Oncostatin M synergistically inhibits HCV RNA replication in combination with interferon-α",

abstract = "Oncostatin M (OSM), a member of the interleukin-6 family, possesses various functions, including hepatocyte differentiation and suppression of melanoma cell growth. Here, we report anti-hepatitis C virus (HCV) activity of OSM as a new function of this cytokine. OSM possessed marked anti-HCV activity (50% effective concentration: 0.71 ng/ml) in an HCV RNA replication cell culture system. The most striking finding is that OSM exhibited synergistic inhibitory activity on interferon (IFN)-α even at a low concentration with weak anti-HCV activity, such as 25 pg/ml. OSM is a candidate anti-HCV reagent and may improve the current IFN therapy for patients with chronic hepatitis C.",

keywords = "Hepatitis C virus, Interferon, Oncostatin M",

author = "Masanori Ikeda and Kyoko Mori and Yasuo Ariumi and Hiromichi Dansako and Nobuyuki Kato",

note = "Funding Information: The authors would like to thank Atsumi Morishita and Takashi Nakamura for their technical assistance. This work was supported by grants-in-aid for a third-term comprehensive 10-year strategy for cancer control and for research on hepatitis from the Ministry of Health, Labor and Welfare of Japan. ",

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T1 - Oncostatin M synergistically inhibits HCV RNA replication in combination with interferon-α

AU - Ikeda, Masanori

AU - Mori, Kyoko

AU - Ariumi, Yasuo

AU - Dansako, Hiromichi

AU - Kato, Nobuyuki

N1 - Funding Information: The authors would like to thank Atsumi Morishita and Takashi Nakamura for their technical assistance. This work was supported by grants-in-aid for a third-term comprehensive 10-year strategy for cancer control and for research on hepatitis from the Ministry of Health, Labor and Welfare of Japan.

PY - 2009/5/6

Y1 - 2009/5/6

N2 - Oncostatin M (OSM), a member of the interleukin-6 family, possesses various functions, including hepatocyte differentiation and suppression of melanoma cell growth. Here, we report anti-hepatitis C virus (HCV) activity of OSM as a new function of this cytokine. OSM possessed marked anti-HCV activity (50% effective concentration: 0.71 ng/ml) in an HCV RNA replication cell culture system. The most striking finding is that OSM exhibited synergistic inhibitory activity on interferon (IFN)-α even at a low concentration with weak anti-HCV activity, such as 25 pg/ml. OSM is a candidate anti-HCV reagent and may improve the current IFN therapy for patients with chronic hepatitis C.

AB - Oncostatin M (OSM), a member of the interleukin-6 family, possesses various functions, including hepatocyte differentiation and suppression of melanoma cell growth. Here, we report anti-hepatitis C virus (HCV) activity of OSM as a new function of this cytokine. OSM possessed marked anti-HCV activity (50% effective concentration: 0.71 ng/ml) in an HCV RNA replication cell culture system. The most striking finding is that OSM exhibited synergistic inhibitory activity on interferon (IFN)-α even at a low concentration with weak anti-HCV activity, such as 25 pg/ml. OSM is a candidate anti-HCV reagent and may improve the current IFN therapy for patients with chronic hepatitis C.

KW - Hepatitis C virus

KW - Interferon

KW - Oncostatin M

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JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

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ER -

Oncostatin M synergistically inhibits HCV RNA replication in combination with interferon-α

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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