Abstract
Oncostatin M (OSM), a member of the interleukin-6 family, possesses various functions, including hepatocyte differentiation and suppression of melanoma cell growth. Here, we report anti-hepatitis C virus (HCV) activity of OSM as a new function of this cytokine. OSM possessed marked anti-HCV activity (50% effective concentration: 0.71 ng/ml) in an HCV RNA replication cell culture system. The most striking finding is that OSM exhibited synergistic inhibitory activity on interferon (IFN)-α even at a low concentration with weak anti-HCV activity, such as 25 pg/ml. OSM is a candidate anti-HCV reagent and may improve the current IFN therapy for patients with chronic hepatitis C.
| Original language | English |
|---|---|
| Pages (from-to) | 1434-1438 |
| Number of pages | 5 |
| Journal | FEBS Letters |
| Volume | 583 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - May 6 2009 |
Keywords
- Hepatitis C virus
- Interferon
- Oncostatin M
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
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Ikeda, M., Mori, K., Ariumi, Y., Dansako, H., & Kato, N. (2009). Oncostatin M synergistically inhibits HCV RNA replication in combination with interferon-α. FEBS Letters, 583(9), 1434-1438. https://doi.org/10.1016/j.febslet.2009.03.054