Abstract
Background: Postprandial elevation of triglycerides impairs endothelial function and contributes to the development of atherosclerosis. We investigated the effects of omega-3 fatty acids on postprandial endothelial function and lipid profiles. Methods: Healthy volunteers [10] were given supplementation at 4. g/day omega-3 fatty acids (or were not treated) for 4 weeks in a randomised crossover study. Postprandial levels of various lipids were monitored and endothelial function assessed by brachial artery flow-mediated dilation during fasting and after a standard cookie test. Results: Omega-3 fatty acids reduced postprandial endothelial dysfunction compared with the control diet (flow-mediated dilation at 4. h. =. -0.5. ±. 1.2 vs. -2.0. ±. 1.6%, P=. 0.03). Postprandial levels of triglycerides, apolipoprotein B-48, and remnant lipoprotein-cholesterol increased in untreated subjects, peaked at 2-4. h, and returned to baseline at 8. h, whereas low-density lipoprotein-cholesterol levels did not change. Supplementation with omega-3 fatty acids significantly suppressed postprandial elevation of triglycerides (incremental area under the curve. =. 220. ±. 209 vs. 374. ±. 216. mg/h/dL, P=. 0.04) and remnant lipoprotein-cholesterol (incremental area under the curve. =. 21.7. ±. 13.8 vs. 13.3. ±. 12.9. mg/h/dL, P=. 0.04). Supplementation with omega-3 fatty acids significantly suppressed the increase in triglyceride content in chylomicrons as well as in very-low-density lipoproteins from baseline to 4. h after the cookie test. Conclusion: Omega-3 fatty acids significantly decreased postprandial triglyceride elevation and postprandial endothelial dysfunction, suggesting that omega-3 fatty acids may have vascular protective effects in postprandial state.
| Original language | English |
|---|---|
| Pages (from-to) | 1071-1077 |
| Number of pages | 7 |
| Journal | Biomedicine and Pharmacotherapy |
| Volume | 68 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Oct 1 2014 |
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Keywords
- Endothelial dysfunction
- Omega-3 fatty acid
- Triglyceride
ASJC Scopus subject areas
- Pharmacology
- Medicine(all)
Cite this
Omega-3 fatty acids improve postprandial lipemia and associated endothelial dysfunction in healthy individuals - a randomized cross-over trial. / Miyoshi, Toru; Noda, Yoko; Ohno, Yuko; Sugiyama, Hiroki; Oe, Hiroki; Nakamura, Kazufumi; Kohno, Kunihisa; Itoh, Hiroshi.
In: Biomedicine and Pharmacotherapy, Vol. 68, No. 8, 01.10.2014, p. 1071-1077.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Omega-3 fatty acids improve postprandial lipemia and associated endothelial dysfunction in healthy individuals - a randomized cross-over trial
AU - Miyoshi, Toru
AU - Noda, Yoko
AU - Ohno, Yuko
AU - Sugiyama, Hiroki
AU - Oe, Hiroki
AU - Nakamura, Kazufumi
AU - Kohno, Kunihisa
AU - Itoh, Hiroshi
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Background: Postprandial elevation of triglycerides impairs endothelial function and contributes to the development of atherosclerosis. We investigated the effects of omega-3 fatty acids on postprandial endothelial function and lipid profiles. Methods: Healthy volunteers [10] were given supplementation at 4. g/day omega-3 fatty acids (or were not treated) for 4 weeks in a randomised crossover study. Postprandial levels of various lipids were monitored and endothelial function assessed by brachial artery flow-mediated dilation during fasting and after a standard cookie test. Results: Omega-3 fatty acids reduced postprandial endothelial dysfunction compared with the control diet (flow-mediated dilation at 4. h. =. -0.5. ±. 1.2 vs. -2.0. ±. 1.6%, P=. 0.03). Postprandial levels of triglycerides, apolipoprotein B-48, and remnant lipoprotein-cholesterol increased in untreated subjects, peaked at 2-4. h, and returned to baseline at 8. h, whereas low-density lipoprotein-cholesterol levels did not change. Supplementation with omega-3 fatty acids significantly suppressed postprandial elevation of triglycerides (incremental area under the curve. =. 220. ±. 209 vs. 374. ±. 216. mg/h/dL, P=. 0.04) and remnant lipoprotein-cholesterol (incremental area under the curve. =. 21.7. ±. 13.8 vs. 13.3. ±. 12.9. mg/h/dL, P=. 0.04). Supplementation with omega-3 fatty acids significantly suppressed the increase in triglyceride content in chylomicrons as well as in very-low-density lipoproteins from baseline to 4. h after the cookie test. Conclusion: Omega-3 fatty acids significantly decreased postprandial triglyceride elevation and postprandial endothelial dysfunction, suggesting that omega-3 fatty acids may have vascular protective effects in postprandial state.
AB - Background: Postprandial elevation of triglycerides impairs endothelial function and contributes to the development of atherosclerosis. We investigated the effects of omega-3 fatty acids on postprandial endothelial function and lipid profiles. Methods: Healthy volunteers [10] were given supplementation at 4. g/day omega-3 fatty acids (or were not treated) for 4 weeks in a randomised crossover study. Postprandial levels of various lipids were monitored and endothelial function assessed by brachial artery flow-mediated dilation during fasting and after a standard cookie test. Results: Omega-3 fatty acids reduced postprandial endothelial dysfunction compared with the control diet (flow-mediated dilation at 4. h. =. -0.5. ±. 1.2 vs. -2.0. ±. 1.6%, P=. 0.03). Postprandial levels of triglycerides, apolipoprotein B-48, and remnant lipoprotein-cholesterol increased in untreated subjects, peaked at 2-4. h, and returned to baseline at 8. h, whereas low-density lipoprotein-cholesterol levels did not change. Supplementation with omega-3 fatty acids significantly suppressed postprandial elevation of triglycerides (incremental area under the curve. =. 220. ±. 209 vs. 374. ±. 216. mg/h/dL, P=. 0.04) and remnant lipoprotein-cholesterol (incremental area under the curve. =. 21.7. ±. 13.8 vs. 13.3. ±. 12.9. mg/h/dL, P=. 0.04). Supplementation with omega-3 fatty acids significantly suppressed the increase in triglyceride content in chylomicrons as well as in very-low-density lipoproteins from baseline to 4. h after the cookie test. Conclusion: Omega-3 fatty acids significantly decreased postprandial triglyceride elevation and postprandial endothelial dysfunction, suggesting that omega-3 fatty acids may have vascular protective effects in postprandial state.
KW - Endothelial dysfunction
KW - Omega-3 fatty acid
KW - Triglyceride
UR - http://www.scopus.com/inward/record.url?scp=84916217631&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84916217631&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2014.10.008
DO - 10.1016/j.biopha.2014.10.008
M3 - Article
VL - 68
SP - 1071
EP - 1077
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
SN - 0753-3322
IS - 8
ER -