Omega-3 fatty acids improve postprandial lipemia and associated endothelial dysfunction in healthy individuals - a randomized cross-over trial

Toru Miyoshi, Yoko Noda, Yuko Ohno, Hiroki Sugiyama, Hiroki Oe, Kazufumi Nakamura, Kunihisa Kohno, Hiroshi Itoh

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Postprandial elevation of triglycerides impairs endothelial function and contributes to the development of atherosclerosis. We investigated the effects of omega-3 fatty acids on postprandial endothelial function and lipid profiles. Methods: Healthy volunteers [10] were given supplementation at 4. g/day omega-3 fatty acids (or were not treated) for 4 weeks in a randomised crossover study. Postprandial levels of various lipids were monitored and endothelial function assessed by brachial artery flow-mediated dilation during fasting and after a standard cookie test. Results: Omega-3 fatty acids reduced postprandial endothelial dysfunction compared with the control diet (flow-mediated dilation at 4. h. =. -0.5. ±. 1.2 vs. -2.0. ±. 1.6%, P=. 0.03). Postprandial levels of triglycerides, apolipoprotein B-48, and remnant lipoprotein-cholesterol increased in untreated subjects, peaked at 2-4. h, and returned to baseline at 8. h, whereas low-density lipoprotein-cholesterol levels did not change. Supplementation with omega-3 fatty acids significantly suppressed postprandial elevation of triglycerides (incremental area under the curve. =. 220. ±. 209 vs. 374. ±. 216. mg/h/dL, P=. 0.04) and remnant lipoprotein-cholesterol (incremental area under the curve. =. 21.7. ±. 13.8 vs. 13.3. ±. 12.9. mg/h/dL, P=. 0.04). Supplementation with omega-3 fatty acids significantly suppressed the increase in triglyceride content in chylomicrons as well as in very-low-density lipoproteins from baseline to 4. h after the cookie test. Conclusion: Omega-3 fatty acids significantly decreased postprandial triglyceride elevation and postprandial endothelial dysfunction, suggesting that omega-3 fatty acids may have vascular protective effects in postprandial state.

Original languageEnglish
Pages (from-to)1071-1077
Number of pages7
JournalBiomedicine and Pharmacotherapy
Volume68
Issue number8
DOIs
Publication statusPublished - Oct 1 2014

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Omega-3 Fatty Acids
Hyperlipidemias
Cross-Over Studies
Triglycerides
Area Under Curve
Dilatation
Apolipoprotein B-48
Lipids
Chylomicrons
Brachial Artery
VLDL Lipoproteins
LDL Cholesterol
Blood Vessels
Fasting
Atherosclerosis
Healthy Volunteers
Diet

Keywords

  • Endothelial dysfunction
  • Omega-3 fatty acid
  • Triglyceride

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

Omega-3 fatty acids improve postprandial lipemia and associated endothelial dysfunction in healthy individuals - a randomized cross-over trial. / Miyoshi, Toru; Noda, Yoko; Ohno, Yuko; Sugiyama, Hiroki; Oe, Hiroki; Nakamura, Kazufumi; Kohno, Kunihisa; Itoh, Hiroshi.

In: Biomedicine and Pharmacotherapy, Vol. 68, No. 8, 01.10.2014, p. 1071-1077.

Research output: Contribution to journalArticle

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abstract = "Background: Postprandial elevation of triglycerides impairs endothelial function and contributes to the development of atherosclerosis. We investigated the effects of omega-3 fatty acids on postprandial endothelial function and lipid profiles. Methods: Healthy volunteers [10] were given supplementation at 4. g/day omega-3 fatty acids (or were not treated) for 4 weeks in a randomised crossover study. Postprandial levels of various lipids were monitored and endothelial function assessed by brachial artery flow-mediated dilation during fasting and after a standard cookie test. Results: Omega-3 fatty acids reduced postprandial endothelial dysfunction compared with the control diet (flow-mediated dilation at 4. h. =. -0.5. ±. 1.2 vs. -2.0. ±. 1.6{\%}, P=. 0.03). Postprandial levels of triglycerides, apolipoprotein B-48, and remnant lipoprotein-cholesterol increased in untreated subjects, peaked at 2-4. h, and returned to baseline at 8. h, whereas low-density lipoprotein-cholesterol levels did not change. Supplementation with omega-3 fatty acids significantly suppressed postprandial elevation of triglycerides (incremental area under the curve. =. 220. ±. 209 vs. 374. ±. 216. mg/h/dL, P=. 0.04) and remnant lipoprotein-cholesterol (incremental area under the curve. =. 21.7. ±. 13.8 vs. 13.3. ±. 12.9. mg/h/dL, P=. 0.04). Supplementation with omega-3 fatty acids significantly suppressed the increase in triglyceride content in chylomicrons as well as in very-low-density lipoproteins from baseline to 4. h after the cookie test. Conclusion: Omega-3 fatty acids significantly decreased postprandial triglyceride elevation and postprandial endothelial dysfunction, suggesting that omega-3 fatty acids may have vascular protective effects in postprandial state.",
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T1 - Omega-3 fatty acids improve postprandial lipemia and associated endothelial dysfunction in healthy individuals - a randomized cross-over trial

AU - Miyoshi, Toru

AU - Noda, Yoko

AU - Ohno, Yuko

AU - Sugiyama, Hiroki

AU - Oe, Hiroki

AU - Nakamura, Kazufumi

AU - Kohno, Kunihisa

AU - Itoh, Hiroshi

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AB - Background: Postprandial elevation of triglycerides impairs endothelial function and contributes to the development of atherosclerosis. We investigated the effects of omega-3 fatty acids on postprandial endothelial function and lipid profiles. Methods: Healthy volunteers [10] were given supplementation at 4. g/day omega-3 fatty acids (or were not treated) for 4 weeks in a randomised crossover study. Postprandial levels of various lipids were monitored and endothelial function assessed by brachial artery flow-mediated dilation during fasting and after a standard cookie test. Results: Omega-3 fatty acids reduced postprandial endothelial dysfunction compared with the control diet (flow-mediated dilation at 4. h. =. -0.5. ±. 1.2 vs. -2.0. ±. 1.6%, P=. 0.03). Postprandial levels of triglycerides, apolipoprotein B-48, and remnant lipoprotein-cholesterol increased in untreated subjects, peaked at 2-4. h, and returned to baseline at 8. h, whereas low-density lipoprotein-cholesterol levels did not change. Supplementation with omega-3 fatty acids significantly suppressed postprandial elevation of triglycerides (incremental area under the curve. =. 220. ±. 209 vs. 374. ±. 216. mg/h/dL, P=. 0.04) and remnant lipoprotein-cholesterol (incremental area under the curve. =. 21.7. ±. 13.8 vs. 13.3. ±. 12.9. mg/h/dL, P=. 0.04). Supplementation with omega-3 fatty acids significantly suppressed the increase in triglyceride content in chylomicrons as well as in very-low-density lipoproteins from baseline to 4. h after the cookie test. Conclusion: Omega-3 fatty acids significantly decreased postprandial triglyceride elevation and postprandial endothelial dysfunction, suggesting that omega-3 fatty acids may have vascular protective effects in postprandial state.

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KW - Omega-3 fatty acid

KW - Triglyceride

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