Olmesartan reduces inflammatory biomarkers in patients with stable coronary artery disease undergoing percutaneous coronary intervention: Results from the OLIVUS trial

Toru Miyoshi, Atsushi Hirohata, Shinichi Usui, Keizo Yamamoto, Takashi Murakami, Issei Komatsubara, Shozo Kusachi, Tohru Ohe, Kazufumi Nakamura, Hiroshi Ito

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Abstract

The OLmesartan on the progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound (OLIVUS) trial demonstrated that an angiotensin II receptor blocker, olmesartan, reduces the rate of coronary atheroma progression as evaluated by intravascular ultrasound in patients with stable angina pectoris undergoing percutaneous coronary intervention. This substudy examined the impact of olmesartan on serum biomarkers and the relationship between biomarker changes and atheroma progression. Patients in the OLIVUS trial (n = 247) were randomly assigned to a control group or the olmesartan group. A subgroup of these patients (n = 135, 55 %) was analyzed at baseline and at 14 months. Patients' characteristics and blood-pressure control were identical between the control group (n = 65) and the olmesartan group (n = 70), and also between the subpopulation and total population. The change in the level of high-sensitivity C-reactive protein (hs-CRP) (mg/l) and adiponectin (μg/ml) was significantly greater in the olmesartan group than in the control group (between-group differences: 0.5 and -0.7; 95 % confidence interval: 0.2-0.8 and -1.3 to -0.1; P = 0.001 and 0.02, respectively). Multiple regression analysis revealed that the nominal changes in total atheroma volume and percent atheroma volume were significantly associated with the nominal change in hs-CRP in the olmesartan group but not in the control group. Olmesartan reduced hs-CRP in patients with stable angina, and this correlated with the change in coronary atheroma.

Original languageEnglish
Pages (from-to)178-185
Number of pages8
JournalHeart and Vessels
Volume29
Issue number2
DOIs
Publication statusPublished - Mar 2014

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Keywords

  • Angiotensin II receptor blocker
  • Coronary artery disease
  • Inflammation
  • Olmesartan

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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