Older age is a risk factor for the development of cardiovascular sequelae in Kawasaki disease

Hiromi Muta, Masahiro Ishii, Takahiko Sakaue, Kimiyasu Egami, Jun Furui, Yoko Sugahara, Teiji Akagi, Yoshikazu Nakamura, Hiroshi Yanagawa, Toyojiro Matsuishi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objectives. To clarify the characteristics of Kawasaki disease (KD) in children 6 years and older and to determine whether age is a risk factor for cardiovascular abnormalities. Methods. Patients who had KD and were reported between 1999 and 2000 in the 16th nationwide survey of KD in Japan (n = 15 314) were analyzed. Patients who were aged 6 years or older (older group) were matched with patients who were aged 6 months to 3 years and were treated at the same hospital (younger groups). The total number of analyzed patients was 1498 (749 matched pairs). Results. The proportion of complete KD in the older group was similar to that in the younger group. Recurrent cases in the older group were significantly more common than those in the younger group (9% vs 2%). The proportion of patients who were treated with intravenous γ-globulin in the older group was significantly lower than that in the younger group (82% vs 87%). The proportion of older group patients who were treated with intravenous γ-globulin at or after 7 days of illness was significantly higher than that in the younger group (35% vs 14%). There was a higher prevalence of cardiovascular abnormalities in the older group than in the younger group (20% vs 15%). Multivariate logistic regression analysis showed that older age was an independent risk factor for cardiovascular sequelae (odds ratio: 1.58; 95% confidence interval: 1.01-2.46). Conclusions. In children older than 6 years, age is an independent risk factor for cardiovascular sequelae in KD.

Original languageEnglish
Pages (from-to)751-754
Number of pages4
JournalPediatrics
Volume114
Issue number3
DOIs
Publication statusPublished - Sep 2004
Externally publishedYes

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Mucocutaneous Lymph Node Syndrome
Cardiovascular Abnormalities
Globulins
Sick Leave
Japan
Research Design
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals

Keywords

  • Cardiovascular sequelae
  • Intravenous γ-globulin
  • Kawasaki disease
  • Older children

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Muta, H., Ishii, M., Sakaue, T., Egami, K., Furui, J., Sugahara, Y., ... Matsuishi, T. (2004). Older age is a risk factor for the development of cardiovascular sequelae in Kawasaki disease. Pediatrics, 114(3), 751-754. https://doi.org/10.1542/peds.2003-0118-F

Older age is a risk factor for the development of cardiovascular sequelae in Kawasaki disease. / Muta, Hiromi; Ishii, Masahiro; Sakaue, Takahiko; Egami, Kimiyasu; Furui, Jun; Sugahara, Yoko; Akagi, Teiji; Nakamura, Yoshikazu; Yanagawa, Hiroshi; Matsuishi, Toyojiro.

In: Pediatrics, Vol. 114, No. 3, 09.2004, p. 751-754.

Research output: Contribution to journalArticle

Muta, H, Ishii, M, Sakaue, T, Egami, K, Furui, J, Sugahara, Y, Akagi, T, Nakamura, Y, Yanagawa, H & Matsuishi, T 2004, 'Older age is a risk factor for the development of cardiovascular sequelae in Kawasaki disease', Pediatrics, vol. 114, no. 3, pp. 751-754. https://doi.org/10.1542/peds.2003-0118-F
Muta, Hiromi ; Ishii, Masahiro ; Sakaue, Takahiko ; Egami, Kimiyasu ; Furui, Jun ; Sugahara, Yoko ; Akagi, Teiji ; Nakamura, Yoshikazu ; Yanagawa, Hiroshi ; Matsuishi, Toyojiro. / Older age is a risk factor for the development of cardiovascular sequelae in Kawasaki disease. In: Pediatrics. 2004 ; Vol. 114, No. 3. pp. 751-754.
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abstract = "Objectives. To clarify the characteristics of Kawasaki disease (KD) in children 6 years and older and to determine whether age is a risk factor for cardiovascular abnormalities. Methods. Patients who had KD and were reported between 1999 and 2000 in the 16th nationwide survey of KD in Japan (n = 15 314) were analyzed. Patients who were aged 6 years or older (older group) were matched with patients who were aged 6 months to 3 years and were treated at the same hospital (younger groups). The total number of analyzed patients was 1498 (749 matched pairs). Results. The proportion of complete KD in the older group was similar to that in the younger group. Recurrent cases in the older group were significantly more common than those in the younger group (9{\%} vs 2{\%}). The proportion of patients who were treated with intravenous γ-globulin in the older group was significantly lower than that in the younger group (82{\%} vs 87{\%}). The proportion of older group patients who were treated with intravenous γ-globulin at or after 7 days of illness was significantly higher than that in the younger group (35{\%} vs 14{\%}). There was a higher prevalence of cardiovascular abnormalities in the older group than in the younger group (20{\%} vs 15{\%}). Multivariate logistic regression analysis showed that older age was an independent risk factor for cardiovascular sequelae (odds ratio: 1.58; 95{\%} confidence interval: 1.01-2.46). Conclusions. In children older than 6 years, age is an independent risk factor for cardiovascular sequelae in KD.",
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AU - Ishii, Masahiro

AU - Sakaue, Takahiko

AU - Egami, Kimiyasu

AU - Furui, Jun

AU - Sugahara, Yoko

AU - Akagi, Teiji

AU - Nakamura, Yoshikazu

AU - Yanagawa, Hiroshi

AU - Matsuishi, Toyojiro

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N2 - Objectives. To clarify the characteristics of Kawasaki disease (KD) in children 6 years and older and to determine whether age is a risk factor for cardiovascular abnormalities. Methods. Patients who had KD and were reported between 1999 and 2000 in the 16th nationwide survey of KD in Japan (n = 15 314) were analyzed. Patients who were aged 6 years or older (older group) were matched with patients who were aged 6 months to 3 years and were treated at the same hospital (younger groups). The total number of analyzed patients was 1498 (749 matched pairs). Results. The proportion of complete KD in the older group was similar to that in the younger group. Recurrent cases in the older group were significantly more common than those in the younger group (9% vs 2%). The proportion of patients who were treated with intravenous γ-globulin in the older group was significantly lower than that in the younger group (82% vs 87%). The proportion of older group patients who were treated with intravenous γ-globulin at or after 7 days of illness was significantly higher than that in the younger group (35% vs 14%). There was a higher prevalence of cardiovascular abnormalities in the older group than in the younger group (20% vs 15%). Multivariate logistic regression analysis showed that older age was an independent risk factor for cardiovascular sequelae (odds ratio: 1.58; 95% confidence interval: 1.01-2.46). Conclusions. In children older than 6 years, age is an independent risk factor for cardiovascular sequelae in KD.

AB - Objectives. To clarify the characteristics of Kawasaki disease (KD) in children 6 years and older and to determine whether age is a risk factor for cardiovascular abnormalities. Methods. Patients who had KD and were reported between 1999 and 2000 in the 16th nationwide survey of KD in Japan (n = 15 314) were analyzed. Patients who were aged 6 years or older (older group) were matched with patients who were aged 6 months to 3 years and were treated at the same hospital (younger groups). The total number of analyzed patients was 1498 (749 matched pairs). Results. The proportion of complete KD in the older group was similar to that in the younger group. Recurrent cases in the older group were significantly more common than those in the younger group (9% vs 2%). The proportion of patients who were treated with intravenous γ-globulin in the older group was significantly lower than that in the younger group (82% vs 87%). The proportion of older group patients who were treated with intravenous γ-globulin at or after 7 days of illness was significantly higher than that in the younger group (35% vs 14%). There was a higher prevalence of cardiovascular abnormalities in the older group than in the younger group (20% vs 15%). Multivariate logistic regression analysis showed that older age was an independent risk factor for cardiovascular sequelae (odds ratio: 1.58; 95% confidence interval: 1.01-2.46). Conclusions. In children older than 6 years, age is an independent risk factor for cardiovascular sequelae in KD.

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