Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation

Takashi Saito; Katsuji Shinagawa; Katsuto Takenaka; Keitaro Matsuo; Tadashi Yoshino; Katsuyuki Kiura; Kenji Niiya; Mine Harada

doi:10.1007/BF02982052

Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation

Takashi Saito, Katsuji Shinagawa, Katsuto Takenaka, Keitaro Matsuo, Tadashi Yoshino, Katsuyuki Kiura, Kenji Niiya, Mine Harada

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

A 26-year-old woman with acute myeloid leukemia underwent allogeneic peripheral blood stem cell transplantation from an HLA-identical brother. Eighteen days after transplantation, the patient developed grade II acute graft-versus-host disease (GVHD) and was treated with corticosteroids. On day 38, the patient complained of eye pain and lacrimation. A slitlamp examination revealed corneal ulcers and pseudomembranous formation in both eyes. Histologic and immunohistochemical examinations of the pseudomembrane disclosed an infiltrate dominated by T cells. A cytogenetic study of the pseudomembrane by fluorescence in situ hybridization identified a Y chromosome in the infiltrated mononuclear cells. Surveillance cultures from conjunctival swabs were negative. Thus, we diagnosed these ocular manifestations as an ocular involvement of acute GVHD.

Original language	English
Pages (from-to)	332-334
Number of pages	3
Journal	International journal of hematology
Volume	75
Issue number	3
DOIs	https://doi.org/10.1007/BF02982052
Publication status	Published - Apr 1 2002

Keywords

Acute graft-versus-host disease
Allogeneic peripheral blood stem cell transplantation
Pseudomembranous conjunctivitis

ASJC Scopus subject areas

Hematology

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10.1007/BF02982052

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abstract = "A 26-year-old woman with acute myeloid leukemia underwent allogeneic peripheral blood stem cell transplantation from an HLA-identical brother. Eighteen days after transplantation, the patient developed grade II acute graft-versus-host disease (GVHD) and was treated with corticosteroids. On day 38, the patient complained of eye pain and lacrimation. A slitlamp examination revealed corneal ulcers and pseudomembranous formation in both eyes. Histologic and immunohistochemical examinations of the pseudomembrane disclosed an infiltrate dominated by T cells. A cytogenetic study of the pseudomembrane by fluorescence in situ hybridization identified a Y chromosome in the infiltrated mononuclear cells. Surveillance cultures from conjunctival swabs were negative. Thus, we diagnosed these ocular manifestations as an ocular involvement of acute GVHD.",

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AU - Saito, Takashi

AU - Shinagawa, Katsuji

AU - Takenaka, Katsuto

AU - Matsuo, Keitaro

AU - Yoshino, Tadashi

AU - Kiura, Katsuyuki

AU - Niiya, Kenji

AU - Harada, Mine

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N2 - A 26-year-old woman with acute myeloid leukemia underwent allogeneic peripheral blood stem cell transplantation from an HLA-identical brother. Eighteen days after transplantation, the patient developed grade II acute graft-versus-host disease (GVHD) and was treated with corticosteroids. On day 38, the patient complained of eye pain and lacrimation. A slitlamp examination revealed corneal ulcers and pseudomembranous formation in both eyes. Histologic and immunohistochemical examinations of the pseudomembrane disclosed an infiltrate dominated by T cells. A cytogenetic study of the pseudomembrane by fluorescence in situ hybridization identified a Y chromosome in the infiltrated mononuclear cells. Surveillance cultures from conjunctival swabs were negative. Thus, we diagnosed these ocular manifestations as an ocular involvement of acute GVHD.

AB - A 26-year-old woman with acute myeloid leukemia underwent allogeneic peripheral blood stem cell transplantation from an HLA-identical brother. Eighteen days after transplantation, the patient developed grade II acute graft-versus-host disease (GVHD) and was treated with corticosteroids. On day 38, the patient complained of eye pain and lacrimation. A slitlamp examination revealed corneal ulcers and pseudomembranous formation in both eyes. Histologic and immunohistochemical examinations of the pseudomembrane disclosed an infiltrate dominated by T cells. A cytogenetic study of the pseudomembrane by fluorescence in situ hybridization identified a Y chromosome in the infiltrated mononuclear cells. Surveillance cultures from conjunctival swabs were negative. Thus, we diagnosed these ocular manifestations as an ocular involvement of acute GVHD.

KW - Acute graft-versus-host disease

KW - Allogeneic peripheral blood stem cell transplantation

KW - Pseudomembranous conjunctivitis

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Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation

Abstract

Keywords

ASJC Scopus subject areas

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