Ocular adnexal marginal zone lymphoma arising in a patient with IgG4-related ophthalmic disease

Kenji Nishida, Yuka Sogabe, Ayako Makihara, Akemi Senoo, Hisanori Morimoto, Mai Takeuchi, Yuka Gion, Tadashi Yoshino, Yasuharu Sato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 41-year-old man was diagnosed with immunoglobulin G4-related disease (IgG4-RD) in both eyelids 4 years ago and exhibited good response to steroid therapy. However, rapid swelling of the right eyelid lesion was recently observed. As IgG4-RD progression was suspected, biopsy was performed. Although the histology was consistent with IgG4-RD, the infiltrating large atypical lymphoid cells showed immunoglobulin light-chain restriction and IgH gene rearrangement. Consequently, he was diagnosed with extranodal marginal zone lymphoma with abundant IgG4-positive cells.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalModern Rheumatology
DOIs
Publication statusAccepted/In press - Aug 10 2016

Fingerprint

Eye Diseases
Immunoglobulins
Lymphoma
Immunoglobulin G
Eyelids
Immunoglobulin Light Chains
Gene Rearrangement
Disease Progression
Histology
Steroids
Lymphocytes
Biopsy
Therapeutics

Keywords

  • IgG4-related disease
  • marginal zone lymphoma
  • ocular adnexa

ASJC Scopus subject areas

  • Rheumatology

Cite this

Ocular adnexal marginal zone lymphoma arising in a patient with IgG4-related ophthalmic disease. / Nishida, Kenji; Sogabe, Yuka; Makihara, Ayako; Senoo, Akemi; Morimoto, Hisanori; Takeuchi, Mai; Gion, Yuka; Yoshino, Tadashi; Sato, Yasuharu.

In: Modern Rheumatology, 10.08.2016, p. 1-5.

Research output: Contribution to journalArticle

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AU - Sato, Yasuharu

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