Ocular adnexal marginal zone lymphoma arising in a patient with IgG4-related ophthalmic disease

Kenji Nishida; Yuka Sogabe; Ayako Makihara; Akemi Senoo; Hisanori Morimoto; Mai Takeuchi; Yuka Gion; Tadashi Yoshino; Yasuharu Sato

doi:10.1080/14397595.2016.1216733

Ocular adnexal marginal zone lymphoma arising in a patient with IgG4-related ophthalmic disease

Kenji Nishida, Yuka Sogabe, Ayako Makihara, Akemi Senoo, Hisanori Morimoto, Mai Takeuchi, Yuka Gion, Tadashi Yoshino, Yasuharu Sato

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

A 41-year-old man was diagnosed with immunoglobulin G4-related disease (IgG4-RD) in both eyelids 4 years ago and exhibited good response to steroid therapy. However, rapid swelling of the right eyelid lesion was recently observed. As IgG4-RD progression was suspected, biopsy was performed. Although the histology was consistent with IgG4-RD, the infiltrating large atypical lymphoid cells showed immunoglobulin light-chain restriction and IgH gene rearrangement. Consequently, he was diagnosed with extranodal marginal zone lymphoma with abundant IgG4-positive cells.

Original language	English
Pages (from-to)	383-387
Number of pages	5
Journal	Modern Rheumatology
Volume	29
Issue number	2
DOIs	https://doi.org/10.1080/14397595.2016.1216733
Publication status	Published - Mar 4 2019

Keywords

IgG4-related disease
marginal zone lymphoma
ocular adnexa

ASJC Scopus subject areas

Rheumatology

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Nishida, K., Sogabe, Y., Makihara, A., Senoo, A., Morimoto, H., Takeuchi, M., Gion, Y., Yoshino, T., & Sato, Y. (2019). Ocular adnexal marginal zone lymphoma arising in a patient with IgG4-related ophthalmic disease. Modern Rheumatology, 29(2), 383-387. https://doi.org/10.1080/14397595.2016.1216733

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abstract = "A 41-year-old man was diagnosed with immunoglobulin G4-related disease (IgG4-RD) in both eyelids 4 years ago and exhibited good response to steroid therapy. However, rapid swelling of the right eyelid lesion was recently observed. As IgG4-RD progression was suspected, biopsy was performed. Although the histology was consistent with IgG4-RD, the infiltrating large atypical lymphoid cells showed immunoglobulin light-chain restriction and IgH gene rearrangement. Consequently, he was diagnosed with extranodal marginal zone lymphoma with abundant IgG4-positive cells.",

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AU - Nishida, Kenji

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AU - Makihara, Ayako

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AU - Morimoto, Hisanori

AU - Takeuchi, Mai

AU - Gion, Yuka

AU - Yoshino, Tadashi

AU - Sato, Yasuharu

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