Ocular adnexal marginal zone lymphoma arising in a patient with IgG4-related ophthalmic disease

Kenji Nishida, Yuka Sogabe, Ayako Makihara, Akemi Senoo, Hisanori Morimoto, Mai Takeuchi, Yuka Gion, Tadashi Yoshino, Yasuharu Sato

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A 41-year-old man was diagnosed with immunoglobulin G4-related disease (IgG4-RD) in both eyelids 4 years ago and exhibited good response to steroid therapy. However, rapid swelling of the right eyelid lesion was recently observed. As IgG4-RD progression was suspected, biopsy was performed. Although the histology was consistent with IgG4-RD, the infiltrating large atypical lymphoid cells showed immunoglobulin light-chain restriction and IgH gene rearrangement. Consequently, he was diagnosed with extranodal marginal zone lymphoma with abundant IgG4-positive cells.

Original languageEnglish
Pages (from-to)383-387
Number of pages5
JournalModern Rheumatology
Volume29
Issue number2
DOIs
Publication statusPublished - Mar 4 2019

Keywords

  • IgG4-related disease
  • marginal zone lymphoma
  • ocular adnexa

ASJC Scopus subject areas

  • Rheumatology

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