Ocular adnexal IgG4-related disease has uniform clinicopathology

Yasuharu Sato, Koh Ichi Ohshima, Kouichi Ichimura, Masakazu Sato, Ichiro Yamadori, Takehiro Tanaka, Katsuyoshi Takata, Toshiaki Morito, Eisaku Kondo, Tadashi Yoshino

Research output: Contribution to journalArticle

214 Citations (Scopus)

Abstract

IgG4-related disease is a recently proposed clinical entity with several unique clinicopathological features. Ocular adnexal IgG4-related disease, however, has not well been clarified. The purpose of the present study was to examine 21 patients (10 men, 11 women; age range, 39-86 years) with ocular adnexal IgG4-related disease. In 17 out of 21 patients (81%), the lacrimal glands were involved and bilateral lacrimal gland swelling was frequently observed (n = 12; 70.6%). In contrast, the conjunctiva was not involved in any of the patient. Histology was uniform with marked lymphoplasmacytic infiltration admixed with dense fibrosis, similar to previous reports of IgG4-related disease. Immunostaining detected numerous aggregates of IgG4-positive plasma cells. Serum IgG4 was higher than normal in 10 of the 13 patients tested, although it was measured after treatment in almost all cases. Interestingly, immunoglobulin heavy chain gene rearrangement was detected in two of 17 patients (12%) examined. The present results show that ocular adnexal IgG4-related disease has uniform clinicopathology: that is, disease involving the bilateral lacrimal glands with lymphoid hyperplasia and fibrosis, but not the conjunctiva. And presence of immunoglobulin heavy chain gene rearrangement suggests the possibility of B-cell lymphoma arising in a background of IgG4-related chronic inflammation.

Original languageEnglish
Pages (from-to)465-470
Number of pages6
JournalPathology International
Volume58
Issue number8
DOIs
Publication statusPublished - Aug 2008

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Immunoglobulin G
Lacrimal Apparatus
Immunoglobulin Heavy Chain Genes
Gene Rearrangement
Conjunctiva
Fibrosis
B-Cell Lymphoma
Plasma Cells
Hyperplasia
Histology
Inflammation
Serum

Keywords

  • Clinicopathological features
  • IgH gene rearrangement
  • Marginal zone B-cell lymphoma
  • Ocular adnexal IgG4-related disease

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Ocular adnexal IgG4-related disease has uniform clinicopathology. / Sato, Yasuharu; Ohshima, Koh Ichi; Ichimura, Kouichi; Sato, Masakazu; Yamadori, Ichiro; Tanaka, Takehiro; Takata, Katsuyoshi; Morito, Toshiaki; Kondo, Eisaku; Yoshino, Tadashi.

In: Pathology International, Vol. 58, No. 8, 08.2008, p. 465-470.

Research output: Contribution to journalArticle

Sato, Y, Ohshima, KI, Ichimura, K, Sato, M, Yamadori, I, Tanaka, T, Takata, K, Morito, T, Kondo, E & Yoshino, T 2008, 'Ocular adnexal IgG4-related disease has uniform clinicopathology', Pathology International, vol. 58, no. 8, pp. 465-470. https://doi.org/10.1111/j.1440-1827.2008.02257.x
Sato, Yasuharu ; Ohshima, Koh Ichi ; Ichimura, Kouichi ; Sato, Masakazu ; Yamadori, Ichiro ; Tanaka, Takehiro ; Takata, Katsuyoshi ; Morito, Toshiaki ; Kondo, Eisaku ; Yoshino, Tadashi. / Ocular adnexal IgG4-related disease has uniform clinicopathology. In: Pathology International. 2008 ; Vol. 58, No. 8. pp. 465-470.
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