Ocular adnexal IgG4-producing mucosa-associated lymphoid tissue lymphoma mimicking IgG4-related disease.

Yasuharu Sato, Koh Ichi Ohshima, Katsuyoshi Takata, Xingang Huang, Wei Cui, Kyotaro Ohno, Tadashi Yoshino

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

IgG4-related disease is a recently proposed clinical entity with several unique clinicopathological features. A chronic inflammatory state with marked fibrosis, which can often be mistaken for malignancy, especially by clinical imaging analyses, unifies these features. In the present report, we describe a case of IgG4-producing mucosa-associated lymphoid tissue lymphoma mimicking IgG4-related disease. The patient was a 55-year-old male who was being followed for right orbital tumor over 1.5 years. The lesion had recently increased in size, so a biopsy was performed. Histologically, the lesion was consistent with IgG4-related disease ; however, IgG4+ plasma cells showed immunoglobulin light-chain restriction and immunoglobulin heavy chain gene rearrangement was detected in the lesion. Therefore, the lesion was diagnosed as IgG4-producing mucosa-associated lymphoid tissue lymphoma. In conclusion, in histological diagnosis of IgG4-related disease, it is important to examine not only IgG4-immunostain but also immunoglobulin light-chain restriction.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalJournal of clinical and experimental hematopathology : JCEH
Volume52
Issue number1
DOIs
Publication statusPublished - 2012

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Marginal Zone B-Cell Lymphoma
Immunoglobulin G
Immunoglobulin Light Chains
Immunoglobulin Heavy Chain Genes
Gene Rearrangement
Plasma Cells
Neoplasms
Fibrosis
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ocular adnexal IgG4-producing mucosa-associated lymphoid tissue lymphoma mimicking IgG4-related disease. / Sato, Yasuharu; Ohshima, Koh Ichi; Takata, Katsuyoshi; Huang, Xingang; Cui, Wei; Ohno, Kyotaro; Yoshino, Tadashi.

In: Journal of clinical and experimental hematopathology : JCEH, Vol. 52, No. 1, 2012, p. 51-55.

Research output: Contribution to journalArticle

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