Occipital alpha connectivity during resting-state electroencephalography in patients with ultra-high risk for psychosis and schizophrenia

Tiantian Liu, Jian Zhang, Xiaonan Dong, Zhucheng Li, Xiaorui Shi, Yizhou Tong, Ruobing Yang, Jinglong Wu, Changming Wang, Ttanyi Yan

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Schizophrenia patients always show cognitive impairment, which is proved to be related to hypo-connectivity or hyper-connectivity. Further, individuals with an ultra-high risk for psychosis also show abnormal functional connectivity-related cognitive impairment, especially in the alpha rhythm. Thus, the identification of functional networks is essential to our understanding of the disorder. We investigated the resting-state functional connectivity of the alpha rhythm measured by electroencephalography (EEG) to reveal the relation between functional network and clinical symptoms. The participants included 28 patients with first-episode schizophrenia (FES), 28 individuals with ultra-high risk for psychosis (UHR), and 28 healthy controls (HC). After the professional clinical symptoms evaluation, all the participants were instructed to keep eyes closed for 3-min resting-state EEG recording. The 3-min EEG data were segmented into artefact-free epochs (the length was 3 s), and the functional connectivity of the alpha phase was estimated using the phase lag index (PLI), which measures the phase differences of EEG signals. The FES and UHR groups displayed increased resting-state PLI connectivity compared with the HC group [F(2, 74) = 10.804, p < 0.001]. Significant increases in the global efficiency, the local efficiency, and the path length were found in the FES and UHR groups compared with those of the HC group. FES and UHR showed an increased degree of connectivity compared with HC. The degree of the left occipital lobe area was higher in the UHR group than in the FES group. The hypothesis of disconnection is confirmed. Furthermore, differences between the UHR and FES group were found, which is valuable for producing clinical significance before the onset of schizophrenia.

Original languageEnglish
Article number553
JournalFrontiers in Psychiatry
Volume10
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes

Keywords

  • Alpha rhythm
  • Functional connectivity
  • Occipital lobe
  • Schizophrenia
  • Ultra-high risk for psychosis

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint

Dive into the research topics of 'Occipital alpha connectivity during resting-state electroencephalography in patients with ultra-high risk for psychosis and schizophrenia'. Together they form a unique fingerprint.

Cite this