Obstructions of portal veins and tumor numbers are associated with humped hepatocellular carcinoma

Takayuki Sanomura, Fusao Ikeda, Tsutomu Katoh, Kazue Hosokawa, Seiyuu Suzuki, Yoshihiro Nishiyama

Research output: Contribution to journalArticlepeer-review


Tumor protrusion in hepatocellular carcinoma (HCC) is one of the risk signs of tumor rupture. Despite curative tumor treatments, HCC recurrences sometimes occur with rapidly growing humped or ruptured HCC in small sized tumors. The aim of this study was to clarify the characteristics of humped HCC clinically and radiologically associated with tumor progression, liver damage, and treatment. The subjects were 179 consecutive HCC patients who underwent angiographic examination. Dynamic studies, using helical computed tomography and magnetic resonance imaging were assessed, and the HCC area were measured. The tumor-node-metastasis (TNM) stage differed significantly between the humped and non-humped HCC groups. Humped HCC was more frequently observed in the right lobe (29.3% of right-lobe HCCs) than in the left (10.1%; p=0.003). Analysis of recurrent HCC revealed that patients with multiple treatments of >4 sessions had more humped HCC (33.8%) than those with 1-3 sessions (16.7%; p-0.042). Multivariate regression analysis revealed that tumor invasion in the portal vein, rather than large tumor size, was significantly associated with tumor protrusion. HCC recurrence with humped HCC occurs often in patients with multiple treatments. Tumor factors of the TNM classification, especially tumor invasion in the portal vein, might be associated with the mechanisms of tumor protrusion.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalActa medica Okayama
Issue number5
Publication statusPublished - 2010
Externally publishedYes


  • Humped HCC
  • Tumor protrusion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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