NY-ESO-1 mRNA expression and immunogenicity in advanced prostate cancer

Tetsuya Nakada, Yuji Noguchi, Shuichiro Satoh, Toshiro Ono, Takashi Saika, Takushi Kurashige, Sacha Gnjatic, Gerd Ritter, Yao Tseng Chen, Elisabeth Stockert, Yasutomo Nasu, Tomoyasu Tsushima, Hiromi Kumon, Lloyd J. Old, Eiichi Nakayama

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

NY-ESO-1 mRNA expression was investigated in advanced prostate cancer by conventional and quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR). NY-ESO-1 mRNA was detected in 20 of 53 (38%) tumor specimens. Four of 15 (27%) stage C, 1 of 3 stage D1 (33%) and 15 of 35 (43%) stage D2 prostate cancers were positive. The presence of NY-ESO-1 antibodies was evaluated in sera from a panel of 218 patients with prostate cancer, including the 53 patients whose tumors were examined for NY-ESO-1 mRNA expression. NY-ESO-1 antibodies were detected in 1 of 30 (3.3%) stage D1 and 9 of 110 (8.2%) stage D2 patients, whereas none of the 78 patients with localized prostate cancer (stages A, B and C) had detectable NY-ESO-1 antibodies. Of the 53 patients whose tumors were examined for NY-ESO-1 mRNA expression, 2 of 20 patients with NY-ESO-1 mRNA-positive tumors had NY-ESO-1 antibodies. No antibody was found in the sera of 32 patients with NY-ESO-1 mRNA-negative tumors, with the exception of one patient with regional lymph node metastasis (stage D1). CD8 T cell responses specific to NY-ESO-1 were detected in two of three patients with NY-ESO-1 antibodies.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalCancer immunity : a journal of the Academy of Cancer Immunology
Volume3
Publication statusPublished - Jul 31 2003

Fingerprint

Prostatic Neoplasms
Messenger RNA
Antibodies
Neoplasms
Serum
Reverse Transcription
Lymph Nodes
Neoplasm Metastasis
T-Lymphocytes
Polymerase Chain Reaction

Keywords

  • Human
  • Immunity
  • mRNA
  • NY-ESO-1
  • Prostate cancer
  • RT-PCR

ASJC Scopus subject areas

  • Cancer Research
  • Immunology

Cite this

Nakada, T., Noguchi, Y., Satoh, S., Ono, T., Saika, T., Kurashige, T., ... Nakayama, E. (2003). NY-ESO-1 mRNA expression and immunogenicity in advanced prostate cancer. Cancer immunity : a journal of the Academy of Cancer Immunology, 3, 1-12.

NY-ESO-1 mRNA expression and immunogenicity in advanced prostate cancer. / Nakada, Tetsuya; Noguchi, Yuji; Satoh, Shuichiro; Ono, Toshiro; Saika, Takashi; Kurashige, Takushi; Gnjatic, Sacha; Ritter, Gerd; Chen, Yao Tseng; Stockert, Elisabeth; Nasu, Yasutomo; Tsushima, Tomoyasu; Kumon, Hiromi; Old, Lloyd J.; Nakayama, Eiichi.

In: Cancer immunity : a journal of the Academy of Cancer Immunology, Vol. 3, 31.07.2003, p. 1-12.

Research output: Contribution to journalArticle

Nakada, T, Noguchi, Y, Satoh, S, Ono, T, Saika, T, Kurashige, T, Gnjatic, S, Ritter, G, Chen, YT, Stockert, E, Nasu, Y, Tsushima, T, Kumon, H, Old, LJ & Nakayama, E 2003, 'NY-ESO-1 mRNA expression and immunogenicity in advanced prostate cancer', Cancer immunity : a journal of the Academy of Cancer Immunology, vol. 3, pp. 1-12.
Nakada, Tetsuya ; Noguchi, Yuji ; Satoh, Shuichiro ; Ono, Toshiro ; Saika, Takashi ; Kurashige, Takushi ; Gnjatic, Sacha ; Ritter, Gerd ; Chen, Yao Tseng ; Stockert, Elisabeth ; Nasu, Yasutomo ; Tsushima, Tomoyasu ; Kumon, Hiromi ; Old, Lloyd J. ; Nakayama, Eiichi. / NY-ESO-1 mRNA expression and immunogenicity in advanced prostate cancer. In: Cancer immunity : a journal of the Academy of Cancer Immunology. 2003 ; Vol. 3. pp. 1-12.
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abstract = "NY-ESO-1 mRNA expression was investigated in advanced prostate cancer by conventional and quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR). NY-ESO-1 mRNA was detected in 20 of 53 (38{\%}) tumor specimens. Four of 15 (27{\%}) stage C, 1 of 3 stage D1 (33{\%}) and 15 of 35 (43{\%}) stage D2 prostate cancers were positive. The presence of NY-ESO-1 antibodies was evaluated in sera from a panel of 218 patients with prostate cancer, including the 53 patients whose tumors were examined for NY-ESO-1 mRNA expression. NY-ESO-1 antibodies were detected in 1 of 30 (3.3{\%}) stage D1 and 9 of 110 (8.2{\%}) stage D2 patients, whereas none of the 78 patients with localized prostate cancer (stages A, B and C) had detectable NY-ESO-1 antibodies. Of the 53 patients whose tumors were examined for NY-ESO-1 mRNA expression, 2 of 20 patients with NY-ESO-1 mRNA-positive tumors had NY-ESO-1 antibodies. No antibody was found in the sera of 32 patients with NY-ESO-1 mRNA-negative tumors, with the exception of one patient with regional lymph node metastasis (stage D1). CD8 T cell responses specific to NY-ESO-1 were detected in two of three patients with NY-ESO-1 antibodies.",
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AU - Saika, Takashi

AU - Kurashige, Takushi

AU - Gnjatic, Sacha

AU - Ritter, Gerd

AU - Chen, Yao Tseng

AU - Stockert, Elisabeth

AU - Nasu, Yasutomo

AU - Tsushima, Tomoyasu

AU - Kumon, Hiromi

AU - Old, Lloyd J.

AU - Nakayama, Eiichi

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