Nutrient conditions sensed by the reproductive organ during development optimize male fecundity in Drosophila

Ayuko Kubo, Mirai Matsuka, Ryunosuke Minami, Fumika Kimura, Rumi Sakata-Niitsu, Akihiko Kokuryo, Kiichiro Taniguchi, Takashi Adachi-Yamada, Hideki Nakagoshi

Research output: Contribution to journalArticle

Abstract

Nutrient conditions affect the reproductive potential and lifespan of many organisms through the insulin signaling pathway. Although this is well characterized in female oogenesis, nutrient-dependent regulation of fertility/fecundity in males is not known. Seminal fluid components synthesized in the accessory gland are required for high fecundity in Drosophila males. The accessory gland is composed of two types of binucleated cells: a main cell and a secondary cell (SC). The transcription factors Defective proventriculus (Dve) and Abdominal-B (Abd-B) are strongly expressed in adult SCs, whose functions are essential for male fecundity. We found that gene expression of both Dve and Abd-B was down-regulated under nutrient-poor conditions. In addition, nutrient conditions during the pupal stage affected the size and number of SCs. These morphological changes clearly correlated with fecundity, suggesting that SCs act as nutrient sensors. Here, we provide evidence that Dve associates nutrient conditions with optimal reproductive potential in a target of rapamycin signaling-dependent manner.

Original languageEnglish
JournalGenes to Cells
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Drosophila
Fertility
Proventriculus
Food
Oogenesis
Sirolimus
Transcription Factors
Insulin
Gene Expression

Keywords

  • Apoptosis
  • Drosophila
  • Fertility
  • Insulin
  • Nutrition
  • Seminal fluid
  • TOR

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Nutrient conditions sensed by the reproductive organ during development optimize male fecundity in Drosophila. / Kubo, Ayuko; Matsuka, Mirai; Minami, Ryunosuke; Kimura, Fumika; Sakata-Niitsu, Rumi; Kokuryo, Akihiko; Taniguchi, Kiichiro; Adachi-Yamada, Takashi; Nakagoshi, Hideki.

In: Genes to Cells, 01.01.2018.

Research output: Contribution to journalArticle

Kubo, A, Matsuka, M, Minami, R, Kimura, F, Sakata-Niitsu, R, Kokuryo, A, Taniguchi, K, Adachi-Yamada, T & Nakagoshi, H 2018, 'Nutrient conditions sensed by the reproductive organ during development optimize male fecundity in Drosophila', Genes to Cells. https://doi.org/10.1111/gtc.12600
Kubo, Ayuko ; Matsuka, Mirai ; Minami, Ryunosuke ; Kimura, Fumika ; Sakata-Niitsu, Rumi ; Kokuryo, Akihiko ; Taniguchi, Kiichiro ; Adachi-Yamada, Takashi ; Nakagoshi, Hideki. / Nutrient conditions sensed by the reproductive organ during development optimize male fecundity in Drosophila. In: Genes to Cells. 2018.
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