Numerical study on flows of red blood cells with liposome-encapsulated hemoglobin at microvascular bifurcation

Toru Hyakutake, Shouko Tominaga, Takeshi Matsumoto, Shinichiro Yanase

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Flow analysis at microvascular bifurcation after partial replacement of red blood cell (RBC) with liposome-encapsulated hemoglobin (LEH) was performed using the lattice Boltzmann method. A two-dimensional symmetric Y bifurcation model with a parent vessel diameter of 20 μm and daughter branch diameters of 20 μm was considered, and the distributions of the RBC, LEH, and oxygen fluxes were calculated. When only RBCs flow into the daughter branches with unevenly distributed flows, plasma separation occurred and the RBC flow to the lower-flow branch was disproportionately decreased. On the other hand, when half of RBC are replaced by LEH, the biasing of RBC flow was enhanced whereas LEH flowed favorably into the lower-flow branch, because many LEH within the parent vessel are suspended in the plasma layer, where no RBCs exist. Consequently, the branched oxygen fluxes became nearly proportional to flows. These results indicate that LEH facilitates oxygen supply to branches that are inaccessible to RBCs.

Original languageEnglish
Article number011014
JournalJournal of Biomechanical Engineering
Volume130
Issue number1
DOIs
Publication statusPublished - Jan 2008

Fingerprint

Liposomes
Hemoglobin
Hemoglobins
Blood
Erythrocytes
Cells
Oxygen
Fluxes
Oxygen supply
Plasma flow
Plasmas

Keywords

  • Biased flux
  • Lattice Boltzmann method
  • Liposome-encapsulated hemoglobin
  • Microvascular bifurcation flow
  • Red blood cell

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics

Cite this

Numerical study on flows of red blood cells with liposome-encapsulated hemoglobin at microvascular bifurcation. / Hyakutake, Toru; Tominaga, Shouko; Matsumoto, Takeshi; Yanase, Shinichiro.

In: Journal of Biomechanical Engineering, Vol. 130, No. 1, 011014, 01.2008.

Research output: Contribution to journalArticle

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