Numerical calculation on a two-step subdiffusion behavior of lateral protein movement in plasma membranes

Tomonari Sumi, Atsushi Okumoto, Hitoshi Goto, Hideo Sekino

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A two-step subdiffusion behavior of lateral movement of transmembrane proteins in plasma membranes has been observed by using single-molecule experiments. A nested double-compartment model where large compartments are divided into several smaller ones has been proposed in order to explain this observation. These compartments are considered to be delimited by membrane-skeleton "fences" and membrane-protein "pickets" bound to the fences. We perform numerical simulations of a master equation using a simple two-dimensional lattice model to investigate the heterogeneous diffusion dynamics behavior of transmembrane proteins within plasma membranes. We show that the experimentally observed two-step subdiffusion process can be described using fence and picket models combined with decreased local diffusivity of transmembrane proteins in the vicinity of the pickets. This allows us to explain the two-step subdiffusion behavior without explicitly introducing nested double compartments.

Original languageEnglish
Article number042410
JournalPhysical Review E
Volume96
Issue number4
DOIs
Publication statusPublished - Oct 19 2017

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

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