TY - JOUR
T1 - NUDT3 rs206936 is associated with body mass index in obese Japanese women
AU - Kitamoto, Aya
AU - Kitamoto, Takuya
AU - Mizusawa, Seiho
AU - Teranishi, Hajime
AU - So, Rina
AU - Matsuo, Tomoaki
AU - Nakata, Yoshio
AU - Hyogo, Hideyuki
AU - Ochi, Hidenori
AU - Nakamura, Takahiro
AU - Kamohara, Seika
AU - Miyatake, Nobuyuki
AU - Kotani, Kazuaki
AU - Komatsu, Ryoya
AU - Itoh, Naoto
AU - Mineo, Ikuo
AU - Wada, Jun
AU - Yoneda, Masato
AU - Nakajima, Atsushi
AU - Funahashi, Tohru
AU - Miyazaki, Shigeru
AU - Tokunaga, Katsuto
AU - Masuzaki, Hiroaki
AU - Ueno, Takato
AU - Chayama, Kazuaki
AU - Hamaguchi, Kazuyuki
AU - Yamada, Kentaro
AU - Hanafusa, Toshiaki
AU - Oikawa, Shinichi
AU - Sakata, Toshiie
AU - Tanaka, Kiyoji
AU - Matsuzawa, Yuji
AU - Nakao, Kazuwa
AU - Sekine, Akihiro
AU - Hotta, Kikuko
PY - 2013
Y1 - 2013
N2 - The predominant risk factor of metabolic syndrome is intra-abdominal fat accumulation, which is determined by waist circumference, waist-hip ratio measurements and visceral fat area (VFA); the latter can be accurately measured by performing computed tomography (CT). In addition to environmental factors, genetic factors play an important role in obesity and fat distribution. New genetic loci associated with body mass index (BMI) and adiposity have been identified by genome-wide association studies (GWASs). This study utilized CT to investigate whether single nucleotide polymorphisms (SNPs) that confer susceptibility to higher BMI are associated with VFA, subcutaneous fat area (SFA), and the ratio of VFA to SFA (V/S ratio). We measured the VFA and SFA of 1424 obese Japanese subjects (BMI ≥ 25 kg/m2, 635 men and 789 women) who were genotyped for 13 single nucleotide polymorphisms (SNPs) reported by recent GWASs, namely, TNNI3K rs1514175, PTBP2 rs1555543, ADCY3 rs713586, IRS1 rs2943650, POC5 rs2112347, NUDT3 rs206936, LINGO2 rs10968576, STK33 rs4929949, MTIF3 rs4771122, SPRY2 rs534870, MAP2K5 rs2241423, QPCTL rs2287019, and ZC3H4 rs3810291. The G-allele of NUDT3 rs206936 was significantly associated with increased BMI (P = 5.3 × 10-5) and SFA (P = 0.00039) in the obese Japanese women. After adjustment with BMI, the association between rs206936 and SFA was not observed. This significant association was not observed in the men. The other SNPs analyzed were not significantly associated with BMI, VFA, SFA, or V/S ratio. Our results suggest that NUDT3 rs206936 is associated with BMI in Japanese women.
AB - The predominant risk factor of metabolic syndrome is intra-abdominal fat accumulation, which is determined by waist circumference, waist-hip ratio measurements and visceral fat area (VFA); the latter can be accurately measured by performing computed tomography (CT). In addition to environmental factors, genetic factors play an important role in obesity and fat distribution. New genetic loci associated with body mass index (BMI) and adiposity have been identified by genome-wide association studies (GWASs). This study utilized CT to investigate whether single nucleotide polymorphisms (SNPs) that confer susceptibility to higher BMI are associated with VFA, subcutaneous fat area (SFA), and the ratio of VFA to SFA (V/S ratio). We measured the VFA and SFA of 1424 obese Japanese subjects (BMI ≥ 25 kg/m2, 635 men and 789 women) who were genotyped for 13 single nucleotide polymorphisms (SNPs) reported by recent GWASs, namely, TNNI3K rs1514175, PTBP2 rs1555543, ADCY3 rs713586, IRS1 rs2943650, POC5 rs2112347, NUDT3 rs206936, LINGO2 rs10968576, STK33 rs4929949, MTIF3 rs4771122, SPRY2 rs534870, MAP2K5 rs2241423, QPCTL rs2287019, and ZC3H4 rs3810291. The G-allele of NUDT3 rs206936 was significantly associated with increased BMI (P = 5.3 × 10-5) and SFA (P = 0.00039) in the obese Japanese women. After adjustment with BMI, the association between rs206936 and SFA was not observed. This significant association was not observed in the men. The other SNPs analyzed were not significantly associated with BMI, VFA, SFA, or V/S ratio. Our results suggest that NUDT3 rs206936 is associated with BMI in Japanese women.
KW - Computed tomography
KW - Japanese
KW - NUDT3
KW - Subcutaneous fat tissue
KW - Visceral adipose tissue
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U2 - 10.1507/endocrj.EJ13-0100
DO - 10.1507/endocrj.EJ13-0100
M3 - Article
C2 - 23708086
AN - SCOPUS:84883369500
VL - 60
SP - 991
EP - 1000
JO - Endocrine Journal
JF - Endocrine Journal
SN - 0918-8959
IS - 8
ER -