Nucleotide Sequence of Endothelin-B receptor Gene Reveals Origin of Piebald Mutation in Laboratory Mouse

Taeko Kumagai, Adumi Wada, Masaoki Tsudzuki, Masahiko Nishimura, Tetsuo Kunieda

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6 Citations (Scopus)


Piebald (Ednrbs) is a coat color mutation of laboratory mice caused by a decreased expression of endothelin-B receptor gene (Ednrb). The IITES and JF1 mouse strains, whose origins are believed to be different from those of the common laboratory inbred strains, also show a phenotype similar to Ednrbs. In the present study, we found that the nucleotide sequence of the Ednrb gene of the IITES and JF1 mice is identical to that of the Ednrbs allele, Ednrbs allele has an RFLP of the Ednrb gene identical with that of M. m. molossinus but different from other subspecies, and at least particular regions of chromosome 14 proximal to the Ednrb locus of the IITES and JF1 strains are derived from M. m. molossinus. These findings clearly indicate that the Ednrbs allele of the laboratory mice has its origin in M. m. molossinus.

Original languageEnglish
Pages (from-to)265-269
Number of pages5
JournalExperimental Animals
Issue number4
Publication statusPublished - Oct 1998



  • Endothelin-B receptor
  • M. m. molossinus
  • Piebald

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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