Nucleotide sequence of a cDNA encoding the chicken receptor protein kinase of the TGF-β receptor family

Tsutomu Nohno, Shoji Sumitomo, Tetsuya Ishikawa, Chiyo Ando, Seikoh Nishida, Sumihare Noji, Taiichi Saito

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We have isolated RPK-2 cDNA from chick embryo cDNA library that encodes a receptor protein kinase of the TGF-β receptor subfamily. The deduced amino acid sequence reveals the presence of a hydrophobic transmembrane helix and a kinase domain distantly related to type II receptor for TGF-β The kinase domain sequence is most similar to RPK-1 identified recently in the chick embryo. Several cysteine residues are contained in the amino-terminal ectodomain, suggesting the protein as a receptor for a peptide growth factor of the TGF-β family.

Original languageEnglish
Pages (from-to)393-396
Number of pages4
JournalMitochondrial DNA
Volume3
Issue number6
DOIs
Publication statusPublished - Jan 1 1993
Externally publishedYes

Keywords

  • CDNA
  • Chick
  • Membrane receptor
  • Protein serine/threonine kinase
  • TGF-β

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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