@article{a92a95475f8b4b2092de34960704b7e3,
title = "Nucleophilic fluoroalkylation/cyclization route to fluorinated phthalides",
abstract = "Discribed in this article is a versatile and practical method for the synthesis of C3-perfluoroalkyl-substituted phthalides in a one-pot manner. Upon treatment of KF or triethylamine, 2-cyanobenzaldehyde reacted with (perfluoroalkyl)trimethylsilanes via nucleophilic addition and subsequent intramolecular cyclization to give perfluoroalkylphthalides in good yields.",
keywords = "Cyclization, Fluorine, Lactone, Phthalide, Trifluoromethylation",
author = "Masanori Inaba and Tatsuya Sakai and Shun Shinada and Tsuyuka Sugiishi and Yuta Nishina and Norio Shibata and Hideki Amii",
note = "Funding Information: This article is dedicated to the memory of Professor Yoshihiko Ito (1937-2006) on the occasion of the 10th anniversary of his sudden death. The financial support of JSPS KAKENHI Grant No. JP 16H04143 (Grant-in-Aid for Scientific Research (B)), JP16H01003 in Precisely Designed Catalysts with Customized Scaffolding, JP16H01129 in Middle Molecular Strategy, and Japan Science and Technology Agency (JST) (ACT-C: Creation of Advanced Catalytic Transformation for the Sustainable Manufacturing at Low Energy, Low Environmental Load) is acknowledged. We would like to thank Prof. Hiroshi Sano (Gunma University) for his useful suggestions. Publisher Copyright: {\textcopyright} 2018 Inaba et al.",
year = "2017",
month = jan,
day = "19",
doi = "10.3762/bjoc.14.12",
language = "English",
volume = "14",
pages = "182--186",
journal = "Beilstein Journal of Organic Chemistry",
issn = "1860-5397",
publisher = "Beilstein-Institut Zur Forderung der Chemischen Wissenschaften",
}