Abstract
One important theme in organic synthesis is to accomplish highly selective transformations under mild conditions, which yield only desirable products. During the past two decades, we have developed several useful tools to achieve this, i.e., organochromium reagents. This review focuses on the following themes: 1) The historical background of organochromium reagents. 2) The development of the allylic chromium reagent (Nozaki-Hiyama reaction). 3) Nickel-catalyzed addition of alkenyl-, aryl-, and alkynyl halides to aldehydes (Nozaki-Hiyama-Kishi (NHK) reaction). 4) Wittig-type olefination with geminal dichromium reagents. 5) Representative applications of organochromium reagents to the total syntheses of biologically active compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 123-131 |
| Number of pages | 9 |
| Journal | Proceedings of the Japan Academy Series B: Physical and Biological Sciences |
| Volume | 76 |
| Issue number | 8 |
| Publication status | Published - Oct 2000 |
Fingerprint
Keywords
- Carbonyl addition
- Chromium
- Nickel
- Organochromium reagent
- Synthetic reaction
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- General
Cite this
Nucleophilic addition of organochromium reagents to carbonyl compounds. / Takai, Kazuhiko; Nozaki, Hitosi.
In: Proceedings of the Japan Academy Series B: Physical and Biological Sciences, Vol. 76, No. 8, 10.2000, p. 123-131.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nucleophilic addition of organochromium reagents to carbonyl compounds
AU - Takai, Kazuhiko
AU - Nozaki, Hitosi
PY - 2000/10
Y1 - 2000/10
N2 - One important theme in organic synthesis is to accomplish highly selective transformations under mild conditions, which yield only desirable products. During the past two decades, we have developed several useful tools to achieve this, i.e., organochromium reagents. This review focuses on the following themes: 1) The historical background of organochromium reagents. 2) The development of the allylic chromium reagent (Nozaki-Hiyama reaction). 3) Nickel-catalyzed addition of alkenyl-, aryl-, and alkynyl halides to aldehydes (Nozaki-Hiyama-Kishi (NHK) reaction). 4) Wittig-type olefination with geminal dichromium reagents. 5) Representative applications of organochromium reagents to the total syntheses of biologically active compounds.
AB - One important theme in organic synthesis is to accomplish highly selective transformations under mild conditions, which yield only desirable products. During the past two decades, we have developed several useful tools to achieve this, i.e., organochromium reagents. This review focuses on the following themes: 1) The historical background of organochromium reagents. 2) The development of the allylic chromium reagent (Nozaki-Hiyama reaction). 3) Nickel-catalyzed addition of alkenyl-, aryl-, and alkynyl halides to aldehydes (Nozaki-Hiyama-Kishi (NHK) reaction). 4) Wittig-type olefination with geminal dichromium reagents. 5) Representative applications of organochromium reagents to the total syntheses of biologically active compounds.
KW - Carbonyl addition
KW - Chromium
KW - Nickel
KW - Organochromium reagent
KW - Synthetic reaction
UR - http://www.scopus.com/inward/record.url?scp=0012689858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0012689858&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0012689858
VL - 76
SP - 123
EP - 131
JO - Proceedings of the Japan Academy Series B: Physical and Biological Sciences
JF - Proceedings of the Japan Academy Series B: Physical and Biological Sciences
SN - 0386-2208
IS - 8
ER -