Nucleophilic addition of organochromium reagents to carbonyl compounds

Kazuhiko Takai, Hitosi Nozaki

Research output: Contribution to journalReview articlepeer-review

57 Citations (Scopus)

Abstract

One important theme in organic synthesis is to accomplish highly selective transformations under mild conditions, which yield only desirable products. During the past two decades, we have developed several useful tools to achieve this, i.e., organochromium reagents. This review focuses on the following themes: 1) The historical background of organochromium reagents. 2) The development of the allylic chromium reagent (Nozaki-Hiyama reaction). 3) Nickel-catalyzed addition of alkenyl-, aryl-, and alkynyl halides to aldehydes (Nozaki-Hiyama-Kishi (NHK) reaction). 4) Wittig-type olefination with geminal dichromium reagents. 5) Representative applications of organochromium reagents to the total syntheses of biologically active compounds.

Original languageEnglish
Pages (from-to)123-131
Number of pages9
JournalProceedings of the Japan Academy Series B: Physical and Biological Sciences
Volume76
Issue number8
DOIs
Publication statusPublished - Oct 2000

Keywords

  • Carbonyl addition
  • Chromium
  • Nickel
  • Organochromium reagent
  • Synthetic reaction

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physics and Astronomy(all)

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