Abstract
One important theme in organic synthesis is to accomplish highly selective transformations under mild conditions, which yield only desirable products. During the past two decades, we have developed several useful tools to achieve this, i.e., organochromium reagents. This review focuses on the following themes: 1) The historical background of organochromium reagents. 2) The development of the allylic chromium reagent (Nozaki-Hiyama reaction). 3) Nickel-catalyzed addition of alkenyl-, aryl-, and alkynyl halides to aldehydes (Nozaki-Hiyama-Kishi (NHK) reaction). 4) Wittig-type olefination with geminal dichromium reagents. 5) Representative applications of organochromium reagents to the total syntheses of biologically active compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 123-131 |
| Number of pages | 9 |
| Journal | Proceedings of the Japan Academy Series B: Physical and Biological Sciences |
| Volume | 76 |
| Issue number | 8 |
| Publication status | Published - Oct 2000 |
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Keywords
- Carbonyl addition
- Chromium
- Nickel
- Organochromium reagent
- Synthetic reaction
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- General
Cite this
Takai, K., & Nozaki, H. (2000). Nucleophilic addition of organochromium reagents to carbonyl compounds. Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 76(8), 123-131.