TY - GEN
T1 - Nuclear physics meets medicine and biology
T2 - 2009 12th International Conference on Nuclear Reaction Mechanisms, NRM 2009
AU - Ballarini, F.
AU - Bakeine, J. G.
AU - Bortolussi, S.
AU - Bruschi, P.
AU - Clerici, A. M.
AU - De Bari, A.
AU - Dionigi, P.
AU - Ferrari, C.
AU - Gadan, M. A.
AU - Protti, N.
AU - Stella, S.
AU - Zonta, C.
AU - Zonta, A.
AU - Altieri, S.
PY - 2010
Y1 - 2010
N2 - BNCT is a tumour treatment based on thermal-neutron irradiation of tissues enriched with 10B, which according to the 10B(n,α) 7Li reaction produces particles with high Linear Energy Transfer and short range. Since this treatment can deliver a therapeutic tumour dose sparing normal tissues, BNCT represents an alternative for diffuse tumours and metastases, which show poor response to surgery and photontherapy. In 2001 and 2003, in Pavia BNCT was applied to an isolated liver, which was infused with boron, explanted, irradiated and re-implanted. A new project was then initiated for lung tumours, developing a protocol for Boron concentration measurements and performing organ-dose Monte Carlo calculations; in parallel, radiobiology studies are ongoing to characterize the BNCT effects down to cellular level. After a brief introduction, herein we will present the main activities ongoing in Pavia including the radiobiological ones, which are under investigation not only experimentally but also theoretically, basing on a Monte Carlo code recently extended to simulate cell killing.
AB - BNCT is a tumour treatment based on thermal-neutron irradiation of tissues enriched with 10B, which according to the 10B(n,α) 7Li reaction produces particles with high Linear Energy Transfer and short range. Since this treatment can deliver a therapeutic tumour dose sparing normal tissues, BNCT represents an alternative for diffuse tumours and metastases, which show poor response to surgery and photontherapy. In 2001 and 2003, in Pavia BNCT was applied to an isolated liver, which was infused with boron, explanted, irradiated and re-implanted. A new project was then initiated for lung tumours, developing a protocol for Boron concentration measurements and performing organ-dose Monte Carlo calculations; in parallel, radiobiology studies are ongoing to characterize the BNCT effects down to cellular level. After a brief introduction, herein we will present the main activities ongoing in Pavia including the radiobiological ones, which are under investigation not only experimentally but also theoretically, basing on a Monte Carlo code recently extended to simulate cell killing.
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M3 - Conference contribution
AN - SCOPUS:84896926890
SN - 9789290833413
T3 - CERN-Proceedings
SP - 561
EP - 571
BT - Proceedings of the 12th International Conference on Nuclear Reaction Mechanisms, NRM 2009
PB - CERN
Y2 - 15 June 2009 through 19 June 2009
ER -