Abstract
Changes in the expression of immediate early gene c-fos by noxious mechanical stimulation to the mandibular incisor pulp of rats were immunohistochemically examined in the hippocampus (Ammon's horn and dentate gyrus) and the retrohippocampus (subiculum, presubiculum, parasubiculum and entorhinal cortex). The highest control levels were found in subiculum, CA1, dentate and deep medial entorhinal cortex. Lower, but substantial levels were present in the other areas. Whereas weak dentinal stimulation caused increases in c-fos expression in some regions which were not statistically significant, strong tooth pulp stimulation caused a bilateral decrease in c- fos expression in every region except contralateral subiculum. These decreases reached statistical significance in superficial layer parasubiculum bilaterally (p <0.01), bilateral CA1 and ipsilateral side of superficial layer of medial entorhinal cortex (p <0.05). We suggest that inhibitory circuitry in hippocampal formation regions may be activated by peripheral noxious somatosensory inputs and this change in activity is accompanied by a change in the expression of the immediate early gene, c-fos.
| Original language | English |
|---|---|
| Pages (from-to) | 215-220 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 827 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - May 8 1999 |
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Keywords
- C-fos
- Hippocampal formation
- Nociception
- Rat
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Noxious tooth pulp stimulation suppresses c-fos expression in the rat hippocampal formation. / Funahashi, Makoto; He, Yi Fen; Sugimoto, Tomosada; Matsuo, Ryuji.
In: Brain Research, Vol. 827, No. 1-2, 08.05.1999, p. 215-220.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Noxious tooth pulp stimulation suppresses c-fos expression in the rat hippocampal formation
AU - Funahashi, Makoto
AU - He, Yi Fen
AU - Sugimoto, Tomosada
AU - Matsuo, Ryuji
PY - 1999/5/8
Y1 - 1999/5/8
N2 - Changes in the expression of immediate early gene c-fos by noxious mechanical stimulation to the mandibular incisor pulp of rats were immunohistochemically examined in the hippocampus (Ammon's horn and dentate gyrus) and the retrohippocampus (subiculum, presubiculum, parasubiculum and entorhinal cortex). The highest control levels were found in subiculum, CA1, dentate and deep medial entorhinal cortex. Lower, but substantial levels were present in the other areas. Whereas weak dentinal stimulation caused increases in c-fos expression in some regions which were not statistically significant, strong tooth pulp stimulation caused a bilateral decrease in c- fos expression in every region except contralateral subiculum. These decreases reached statistical significance in superficial layer parasubiculum bilaterally (p <0.01), bilateral CA1 and ipsilateral side of superficial layer of medial entorhinal cortex (p <0.05). We suggest that inhibitory circuitry in hippocampal formation regions may be activated by peripheral noxious somatosensory inputs and this change in activity is accompanied by a change in the expression of the immediate early gene, c-fos.
AB - Changes in the expression of immediate early gene c-fos by noxious mechanical stimulation to the mandibular incisor pulp of rats were immunohistochemically examined in the hippocampus (Ammon's horn and dentate gyrus) and the retrohippocampus (subiculum, presubiculum, parasubiculum and entorhinal cortex). The highest control levels were found in subiculum, CA1, dentate and deep medial entorhinal cortex. Lower, but substantial levels were present in the other areas. Whereas weak dentinal stimulation caused increases in c-fos expression in some regions which were not statistically significant, strong tooth pulp stimulation caused a bilateral decrease in c- fos expression in every region except contralateral subiculum. These decreases reached statistical significance in superficial layer parasubiculum bilaterally (p <0.01), bilateral CA1 and ipsilateral side of superficial layer of medial entorhinal cortex (p <0.05). We suggest that inhibitory circuitry in hippocampal formation regions may be activated by peripheral noxious somatosensory inputs and this change in activity is accompanied by a change in the expression of the immediate early gene, c-fos.
KW - C-fos
KW - Hippocampal formation
KW - Nociception
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=0033535740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033535740&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(99)01250-0
DO - 10.1016/S0006-8993(99)01250-0
M3 - Article
C2 - 10320712
AN - SCOPUS:0033535740
VL - 827
SP - 215
EP - 220
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -