Novel transdermal drug delivery system with polyhydroxyalkanoate and starburst polyamidoamine dendrimer

Zhioxiong Wang, Yoshiaki Itoh, Yoshifumi Hosaka, Ichiro Kobayashi, Yoshihisa Nakano, Isamu Maeda, Fusako Umeda, Junji Yamakawa, Masaya Kawase, Kiyohito Yagi

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

In search of an efficient transdermal drug delivery system (TDDS), a polyhydroxyalkanoate (PHA)-based system with a polyamidoamine dendrimer was examined. Tamsulosin was used as the model drug. The dendrimer was found to act as the weak enhancer. By adding the dendrimer, the dendrimer-containing PHA matrix achieved the clinically required amount of tamsulosin permeating through the skin model. This is also the first report of the application of PHA and dendrimer to the TDDS.

Original languageEnglish
Pages (from-to)541-543
Number of pages3
JournalJournal of Bioscience and Bioengineering
Volume95
Issue number5
DOIs
Publication statusPublished - Jan 1 2003

Keywords

  • Dendrimer
  • Polyhydroxyalkanoate
  • Tamsulosin
  • Transdermal drug delivery system

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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    Wang, Z., Itoh, Y., Hosaka, Y., Kobayashi, I., Nakano, Y., Maeda, I., Umeda, F., Yamakawa, J., Kawase, M., & Yagi, K. (2003). Novel transdermal drug delivery system with polyhydroxyalkanoate and starburst polyamidoamine dendrimer. Journal of Bioscience and Bioengineering, 95(5), 541-543. https://doi.org/10.1263/jbb.95.541