Novel tissue and cell type-specific gene/drug delivery system using surface engineered hepatitis B virus nano-particles

Tadanori Yamada, Masakazu Ueda, Masaharu Seno, Akihiko Kondo, Katsuyuki Tanizawa, Shun'ichi Kuroda

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)

Abstract

The hepatitis B virus (HBV) surface antigen (HBsAg) L particle is a hollow nano-scale particle. HBsAg L particles have many properties that make them useful for in vivo gene transfer vectors and drug delivery systems. Gene therapy so far has required the in vivo pinpoint delivery of genetic materials into the target organs and cells. Gene transfer by HBsAg L particles might be an attractive method, since their tropism is the same as that of HBV. The HBsAg L particles are able to deliver therapeutic payloads with high specificity to human hepatocytes. In addition, the specificity of L particle can be altered by displaying various cell-binding molecules on the surface. Our results indicate that the L particle is suitable for a cell- and tissue-specific gene/drug transfer vector. In this review, we discuss HBsAg L particles as a gene/drug transfer vector and its potential for the treatment of infectious diseases.

Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalCurrent Drug Targets - Infectious Disorders
Volume4
Issue number2
DOIs
Publication statusPublished - Jun 30 2004

Keywords

  • Drug system
  • Gene delivery
  • HBsAg L particle
  • in vivo system

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Microbiology (medical)

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