Novel synthesis of benzoxazoles from o-nitrophenols and amines

Hiromi Nishioka, Yukiko Ohmori, Yumiko Iba, Eri Tsuda, Takashi Harayama

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

o-Nitrophenols and o-nitroaniline were reacted with amines at 210-215°C to produce the corresponding benzoxazoles and benzimidazoles, respectively, in moderate yields. The reactions between o-nitrophenols containing a CO2Me or OMe group on their benzene rings and N,N-diethylaniline were examined to investigate the effects of the position and electronic character of these substituents on the formation of the oxazole ring.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalHeterocycles
Volume64
DOIs
Publication statusPublished - Dec 31 2004

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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