Novel synthesis of 4-chloro-3-hydroxy-2-pyrone by the reaction of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride

Takuzo Komiyama; Yutaka Takaguchi; Sadao Tsuboi

doi:10.1016/j.tetlet.2004.06.101

Novel synthesis of 4-chloro-3-hydroxy-2-pyrone by the reaction of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride

Takuzo Komiyama, Yutaka Takaguchi, Sadao Tsuboi

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Treatment of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride gave 4-chloro-3-hydroxy-2-pyrone in excellent to good yields. Treatment of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride gave 4-chloro-3-hydroxy-2-pyrone in excellent to good yields.

Original language	English
Pages (from-to)	6299-6301
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	33
DOIs	https://doi.org/10.1016/j.tetlet.2004.06.101
Publication status	Published - Aug 9 2004

Keywords

2-Pyrone
Cyclization
Darzens condensation
Dichloroacetate
Magnesium chloride

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2004.06.101

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abstract = "Treatment of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride gave 4-chloro-3-hydroxy-2-pyrone in excellent to good yields. Treatment of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride gave 4-chloro-3-hydroxy-2-pyrone in excellent to good yields.",

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author = "Takuzo Komiyama and Yutaka Takaguchi and Sadao Tsuboi",

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AU - Komiyama, Takuzo

AU - Takaguchi, Yutaka

AU - Tsuboi, Sadao

PY - 2004/8/9

Y1 - 2004/8/9

N2 - Treatment of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride gave 4-chloro-3-hydroxy-2-pyrone in excellent to good yields. Treatment of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride gave 4-chloro-3-hydroxy-2-pyrone in excellent to good yields.

AB - Treatment of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride gave 4-chloro-3-hydroxy-2-pyrone in excellent to good yields. Treatment of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride gave 4-chloro-3-hydroxy-2-pyrone in excellent to good yields.

KW - 2-Pyrone

KW - Cyclization

KW - Darzens condensation

KW - Dichloroacetate

KW - Magnesium chloride

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 33

ER -

Novel synthesis of 4-chloro-3-hydroxy-2-pyrone by the reaction of acetonide protected 4,5-dihydroxy-2-chloroglycidic ester with magnesium chloride

Abstract

Keywords

ASJC Scopus subject areas

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