Novel route to the synthesis of hydroxylated pyrrolidine derivatives via the intramolecular reaction of γ-aminoallylstannane with aldehyde. Total synthesis of (+)-preussin

Isao Kadota, Shioko Saya, Yoshinori Yamamoto

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

The thermal cyclization of γ-aminoallylstannane (8) having an aldehyde group gave β-hydroxypyrrolidine derivative (9a) as a sole product. This methodology was applied successfully to the total synthesis of (+)-preussin.

Original languageEnglish
Pages (from-to)335-348
Number of pages14
JournalHeterocycles
Volume46
Issue number1
Publication statusPublished - Dec 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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