Novel route to the synthesis of hydroxylated pyrrolidine derivatives via the intramolecular reaction of γ-aminoallylstannane with aldehyde. Total synthesis of (+)-preussin

Isao Kadota, Shioko Saya, Yoshinori Yamamoto

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20 Citations (Scopus)

Abstract

The thermal cyclization of γ-aminoallylstannane (8) having an aldehyde group gave β-hydroxypyrrolidine derivative (9a) as a sole product. This methodology was applied successfully to the total synthesis of (+)-preussin.

Original languageEnglish
Pages (from-to)335-348
Number of pages14
JournalHeterocycles
Volume46
Issue number1
Publication statusPublished - 1997
Externally publishedYes

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preussin
Cyclization
Aldehydes
Hot Temperature
Derivatives
pyrrolidine

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

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title = "Novel route to the synthesis of hydroxylated pyrrolidine derivatives via the intramolecular reaction of γ-aminoallylstannane with aldehyde. Total synthesis of (+)-preussin",
abstract = "The thermal cyclization of γ-aminoallylstannane (8) having an aldehyde group gave β-hydroxypyrrolidine derivative (9a) as a sole product. This methodology was applied successfully to the total synthesis of (+)-preussin.",
author = "Isao Kadota and Shioko Saya and Yoshinori Yamamoto",
year = "1997",
language = "English",
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journal = "Heterocycles",
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publisher = "Japan Institute of Heterocyclic Chemistry",
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T1 - Novel route to the synthesis of hydroxylated pyrrolidine derivatives via the intramolecular reaction of γ-aminoallylstannane with aldehyde. Total synthesis of (+)-preussin

AU - Kadota, Isao

AU - Saya, Shioko

AU - Yamamoto, Yoshinori

PY - 1997

Y1 - 1997

N2 - The thermal cyclization of γ-aminoallylstannane (8) having an aldehyde group gave β-hydroxypyrrolidine derivative (9a) as a sole product. This methodology was applied successfully to the total synthesis of (+)-preussin.

AB - The thermal cyclization of γ-aminoallylstannane (8) having an aldehyde group gave β-hydroxypyrrolidine derivative (9a) as a sole product. This methodology was applied successfully to the total synthesis of (+)-preussin.

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M3 - Article

VL - 46

SP - 335

EP - 348

JO - Heterocycles

JF - Heterocycles

SN - 0385-5414

IS - 1

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