The Lewis acid mediated intramolecular reaction of gamma-aminoallyl-stannane 6 gave trans-beta-hydroxypiperidine derivative 7a as a major product. On the other hand, the thermal cyclization of 6 and 8 afforded cis-beta-hydroxypiperidine 7b and pyrrolidine derivative 9b, respectively, with very high stereoselectivity.
|Number of pages||4|
|Publication status||Published - Mar 18 1996|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry