Novel pathogenic role of fibrin as revealed by a case study on ligneous gingivitis

Tsuyoshi Shimo, Akiyoshi Nishiyama, Satoshi Kubota, Naito Kurio, Tatsuo Okui, Naoki Katase, Nur Mohammad Monsur Hassan, Tatsuki Honami, Koji Kishimoto, Hiroshi Mese, Masaharu Takigawa, Akira Sasaki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose of the research: Ligneous gingivitis is a rare disease characterized by nodular gingival enlargement secondary to fibrin deposits induced by micro-injury in the gingiva, which disorder results from plasminogen (PLG) deficiency. Although none have investigated the association of wound healing factors with ligneous gingivitis. In this study, in addition to a histopathologic examination of ligneous gingivitis in a case of type I PLG deficiency, we further present data showing the effect of wound healing factors in association with fibrin in vitro to clarify the pathobiology of ligneous gingivitis in PLG-deficient patients. Principle results: Immunohistochemical analysis revealed that transforming growth factor (TGF)-β1, connective tissue growth factor/CCN2 (CCN2), and endothelin-1 (ET-1) had accumulated in the extracellular matrix around the epithelial and fibroblastic cells near the fibrin deposition. Consistent with these results, fibrin and TGF-β1 synergistically up-regulated CCN2 and ET-1 gene expression in human dermal fibroblasts. Major conclusions: Fibrin plays a vicious role in ligneous gingivitis pathobiology by up-regulating CCN2 and ET-1 expression through the TGF-β signaling pathway.

Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalOral Science International
Volume8
Issue number2
DOIs
Publication statusPublished - Nov 2011

Fingerprint

Gingivitis
Fibrin
Transforming Growth Factors
Endothelin-1
Plasminogen
Wound Healing
Connective Tissue Growth Factor
Gingiva
Rare Diseases
Extracellular Matrix
Fibroblasts
Epithelial Cells
Gene Expression
Skin
Wounds and Injuries
Research

Keywords

  • Connective tissue growth factor
  • Fibrin
  • Ligneous gingivitis
  • Plasminogen

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Novel pathogenic role of fibrin as revealed by a case study on ligneous gingivitis. / Shimo, Tsuyoshi; Nishiyama, Akiyoshi; Kubota, Satoshi; Kurio, Naito; Okui, Tatsuo; Katase, Naoki; Hassan, Nur Mohammad Monsur; Honami, Tatsuki; Kishimoto, Koji; Mese, Hiroshi; Takigawa, Masaharu; Sasaki, Akira.

In: Oral Science International, Vol. 8, No. 2, 11.2011, p. 44-49.

Research output: Contribution to journalArticle

Shimo, Tsuyoshi ; Nishiyama, Akiyoshi ; Kubota, Satoshi ; Kurio, Naito ; Okui, Tatsuo ; Katase, Naoki ; Hassan, Nur Mohammad Monsur ; Honami, Tatsuki ; Kishimoto, Koji ; Mese, Hiroshi ; Takigawa, Masaharu ; Sasaki, Akira. / Novel pathogenic role of fibrin as revealed by a case study on ligneous gingivitis. In: Oral Science International. 2011 ; Vol. 8, No. 2. pp. 44-49.
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