TY - JOUR
T1 - Novel pathogenic role of fibrin as revealed by a case study on ligneous gingivitis
AU - Shimo, Tsuyoshi
AU - Nishiyama, Akiyoshi
AU - Kubota, Satoshi
AU - Kurio, Naito
AU - Okui, Tatsuo
AU - Katase, Naoki
AU - Hassan, Nur Mohammad Monsur
AU - Honami, Tatsuki
AU - Kishimoto, Koji
AU - Mese, Hiroshi
AU - Takigawa, Masaharu
AU - Sasaki, Akira
PY - 2011/11
Y1 - 2011/11
N2 - Purpose of the research: Ligneous gingivitis is a rare disease characterized by nodular gingival enlargement secondary to fibrin deposits induced by micro-injury in the gingiva, which disorder results from plasminogen (PLG) deficiency. Although none have investigated the association of wound healing factors with ligneous gingivitis. In this study, in addition to a histopathologic examination of ligneous gingivitis in a case of type I PLG deficiency, we further present data showing the effect of wound healing factors in association with fibrin in vitro to clarify the pathobiology of ligneous gingivitis in PLG-deficient patients. Principle results: Immunohistochemical analysis revealed that transforming growth factor (TGF)-β1, connective tissue growth factor/CCN2 (CCN2), and endothelin-1 (ET-1) had accumulated in the extracellular matrix around the epithelial and fibroblastic cells near the fibrin deposition. Consistent with these results, fibrin and TGF-β1 synergistically up-regulated CCN2 and ET-1 gene expression in human dermal fibroblasts. Major conclusions: Fibrin plays a vicious role in ligneous gingivitis pathobiology by up-regulating CCN2 and ET-1 expression through the TGF-β signaling pathway.
AB - Purpose of the research: Ligneous gingivitis is a rare disease characterized by nodular gingival enlargement secondary to fibrin deposits induced by micro-injury in the gingiva, which disorder results from plasminogen (PLG) deficiency. Although none have investigated the association of wound healing factors with ligneous gingivitis. In this study, in addition to a histopathologic examination of ligneous gingivitis in a case of type I PLG deficiency, we further present data showing the effect of wound healing factors in association with fibrin in vitro to clarify the pathobiology of ligneous gingivitis in PLG-deficient patients. Principle results: Immunohistochemical analysis revealed that transforming growth factor (TGF)-β1, connective tissue growth factor/CCN2 (CCN2), and endothelin-1 (ET-1) had accumulated in the extracellular matrix around the epithelial and fibroblastic cells near the fibrin deposition. Consistent with these results, fibrin and TGF-β1 synergistically up-regulated CCN2 and ET-1 gene expression in human dermal fibroblasts. Major conclusions: Fibrin plays a vicious role in ligneous gingivitis pathobiology by up-regulating CCN2 and ET-1 expression through the TGF-β signaling pathway.
KW - Connective tissue growth factor
KW - Fibrin
KW - Ligneous gingivitis
KW - Plasminogen
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U2 - 10.1016/S1348-8643(11)00025-5
DO - 10.1016/S1348-8643(11)00025-5
M3 - Article
AN - SCOPUS:84857839384
VL - 8
SP - 44
EP - 49
JO - Oral Science International
JF - Oral Science International
SN - 1348-8643
IS - 2
ER -