Novel modification of 5-formyluracil by cysteine derivatives in aqueous solution

Hiroaki Terato, Hajime Morita, Yoshihiko Ohyama, Hiroshi Ide

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Reactivities of 5-formyl-2'-deoxyuridine (fdU) and its 5'-monophosphate (fdUMP) to amino acids, amines and thiol compounds in neutral aqueous solution have been studied to elucidate the postmodification of the 5- formyluracil (fU) moiety in cells. fdU and fdUMP specifically reacted with cysteine and its analogs to form thiazolidine derivatives. The reaction involved condensation of the formyl group of fU with both α-NH2(or NH2 at the equivalent position) and SH groups of cysteine derivatives.

Original languageEnglish
Pages (from-to)131-141
Number of pages11
JournalNucleosides and Nucleotides
Volume17
Issue number1-3
Publication statusPublished - Apr 8 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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