Abstract
Midkine is a heparin-binding growth factor highly expressed in various human malignant tumors. However, its role in the growth of oral squamous cell carcinoma is not well understood. In this study, we analyzed the antitumor effect of a novel midkine inhibitor (iMDK) against oral squamous cell carcinoma. Administration of iMDK induced a robust antitumor response and suppressed cluster of differentiation 31 (CD31) expression in oral squamous cell carcinoma HSC-2 cells and SAS cells xenograft models. iMDK inhibited the proliferation of these cells dose-dependently, as well as the expression of midkine and phospho-extracellular signal-regulated kinase in HSC-2 and SAS cells. Moreover, iMDK significantly inhibited vascular endothelial growth factor and induced tube growth of human umbilical vein endothelial cells in a dose-dependent fashion. These findings suggest that midkine is critically involved in oral squamous cell carcinoma and iMDK can be effectively used for the treatment of oral squamous cell carcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 2775-2781 |
| Number of pages | 7 |
| Journal | Anticancer Research |
| Volume | 36 |
| Issue number | 6 |
| Publication status | Published - Jun 1 2016 |
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Keywords
- Angiogenesis
- IMDK
- Midkine
- Oral squamous cell carcinoma
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Novel midkine inhibitor iMDK inhibits tumor growth and angiogenesis in oral squamous cell carcinoma. / Masui, Masanori; Okui, Tatsuo; Shimo, Tsuyoshi; Takabatake, Kiyofumi; Fukazawa, Takuya; Matsumoto, Kenichi; Kurio, Naito; Ibaragi, Soichiro; Naomoto, Yoshio; Nagatsuka, Hitoshi; Sasaki, Akira.
In: Anticancer Research, Vol. 36, No. 6, 01.06.2016, p. 2775-2781.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Novel midkine inhibitor iMDK inhibits tumor growth and angiogenesis in oral squamous cell carcinoma
AU - Masui, Masanori
AU - Okui, Tatsuo
AU - Shimo, Tsuyoshi
AU - Takabatake, Kiyofumi
AU - Fukazawa, Takuya
AU - Matsumoto, Kenichi
AU - Kurio, Naito
AU - Ibaragi, Soichiro
AU - Naomoto, Yoshio
AU - Nagatsuka, Hitoshi
AU - Sasaki, Akira
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Midkine is a heparin-binding growth factor highly expressed in various human malignant tumors. However, its role in the growth of oral squamous cell carcinoma is not well understood. In this study, we analyzed the antitumor effect of a novel midkine inhibitor (iMDK) against oral squamous cell carcinoma. Administration of iMDK induced a robust antitumor response and suppressed cluster of differentiation 31 (CD31) expression in oral squamous cell carcinoma HSC-2 cells and SAS cells xenograft models. iMDK inhibited the proliferation of these cells dose-dependently, as well as the expression of midkine and phospho-extracellular signal-regulated kinase in HSC-2 and SAS cells. Moreover, iMDK significantly inhibited vascular endothelial growth factor and induced tube growth of human umbilical vein endothelial cells in a dose-dependent fashion. These findings suggest that midkine is critically involved in oral squamous cell carcinoma and iMDK can be effectively used for the treatment of oral squamous cell carcinoma.
AB - Midkine is a heparin-binding growth factor highly expressed in various human malignant tumors. However, its role in the growth of oral squamous cell carcinoma is not well understood. In this study, we analyzed the antitumor effect of a novel midkine inhibitor (iMDK) against oral squamous cell carcinoma. Administration of iMDK induced a robust antitumor response and suppressed cluster of differentiation 31 (CD31) expression in oral squamous cell carcinoma HSC-2 cells and SAS cells xenograft models. iMDK inhibited the proliferation of these cells dose-dependently, as well as the expression of midkine and phospho-extracellular signal-regulated kinase in HSC-2 and SAS cells. Moreover, iMDK significantly inhibited vascular endothelial growth factor and induced tube growth of human umbilical vein endothelial cells in a dose-dependent fashion. These findings suggest that midkine is critically involved in oral squamous cell carcinoma and iMDK can be effectively used for the treatment of oral squamous cell carcinoma.
KW - Angiogenesis
KW - IMDK
KW - Midkine
KW - Oral squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84991698884&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84991698884&partnerID=8YFLogxK
M3 - Article
VL - 36
SP - 2775
EP - 2781
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 6
ER -