Novel metabolic pathways of organochlorine pesticides dieldrin and aldrin by the white rot fungi of the genus Phlebia

Pengfei Xiao, Toshio Mori, Ichiro Kamei, Hiromasa Kiyota, Kazuhiro Takagi, Ryuichiro Kondo

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

White rot fungi can degrade a wide spectrum of recalcitrant organic pollutants, including polychlorinated dibenzo-. p-dioxins (PCDDs) and polychlorinated biphenyls (PCBs). In this experiment, 20 white rot fungi, belonging to genus Phlebia, were investigated for their ability to degrade dieldrin. Based on the screening results, we further investigated Phlebia acanthocystis, Phlebia brevispora, and Phlebia aurea to determine their degradation capacity and metabolic products towards dieldrin and aldrin. The three fungi were able to remove over 50% of dieldrin in a low nitrogen medium, after 42. d of incubation. Three hydroxylated products were detected as metabolites of dieldrin, suggesting that in Phlebia strains, hydroxylation reactions might play an important role in the metabolism of dieldrin. In contrast to dieldrin, aldrin exhibited higher levels of degradation activity. Over 90% of aldrin was removed after 28. d of incubation, and several new metabolites of aldrin in microorganisms, including 9-hydroxyaldrin and two carboxylic acid products, were detected in fungal cultures. These results indicate that the methylene moiety of aldrin and dieldrin molecules might be prone to enzymatic attack by white rot fungi. In this study, we describe for the first time a new metabolic pathway of both compounds by fungi of genus Phlebia.

Original languageEnglish
Pages (from-to)218-224
Number of pages7
JournalChemosphere
Volume85
Issue number2
DOIs
Publication statusPublished - Sep 2011
Externally publishedYes

Fingerprint

Aldrin
Dieldrin
dieldrin
Pesticides
Metabolic Networks and Pathways
Fungi
fungus
Metabolites
Degradation
Hydroxylation
metabolite
Organic pollutants
incubation
Polychlorinated biphenyls
Carboxylic acids
Metabolism
Microorganisms
degradation
Screening
Polychlorinated Biphenyls

Keywords

  • Aldrin
  • Dieldrin
  • Hydroxylation
  • Metabolism
  • Phlebia
  • White rot fungi

ASJC Scopus subject areas

  • Environmental Chemistry
  • Chemistry(all)

Cite this

Novel metabolic pathways of organochlorine pesticides dieldrin and aldrin by the white rot fungi of the genus Phlebia. / Xiao, Pengfei; Mori, Toshio; Kamei, Ichiro; Kiyota, Hiromasa; Takagi, Kazuhiro; Kondo, Ryuichiro.

In: Chemosphere, Vol. 85, No. 2, 09.2011, p. 218-224.

Research output: Contribution to journalArticle

Xiao, Pengfei ; Mori, Toshio ; Kamei, Ichiro ; Kiyota, Hiromasa ; Takagi, Kazuhiro ; Kondo, Ryuichiro. / Novel metabolic pathways of organochlorine pesticides dieldrin and aldrin by the white rot fungi of the genus Phlebia. In: Chemosphere. 2011 ; Vol. 85, No. 2. pp. 218-224.
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