Novel inhibitors of poly(ADP-ribose) glycohydrolase

Kazuma Aoki, Koji Nishimura, Hideaki Abe, Hideharu Maruta, Hiroshi Sakagami, Tsutomu Hatano, Takuo Okuda, Takashi Yoshida, Yan Jyu Tsai, Fumiaki Uchiumi, Sei ichi Tanuma

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The inhibitory effects on poly(ADP-ribose) glycohydrolase purified from human placenta of three classes of chemically defined tannins; gallotannins; ellagitannins and condensed tannins, were examined in vitro. Oligometric ellagitannins were found to be most potent inhibitors of poly(ADP-ribose) glycohydrolase, their potencies increasing with increasing number of monomeric residues (dinner <trimer <tetramer). Monomeric ellagitannins and gallotannins were less inhibitory. Condensed tannins, which consist of an epicatechin gallate oligomer without a glucose core, were not appreciably inhibitory. A structure-activity study showed that higher-order confirmations of the conjugates with glucose of hexahydroxydiphenoyl and valoneoyl groups, which are unique components of ellegitannins, cooperatively potentiated the inhibitory activity.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalBiochimica et Biophysica Acta - General Subjects
Volume1158
Issue number3
DOIs
Publication statusPublished - Nov 28 1993

Fingerprint

Hydrolyzable Tannins
Proanthocyanidins
Glucose
Tannins
Oligomers
Placenta
Meals
poly ADP-ribose glycohydrolase

Keywords

  • Ellagitannin
  • Enzyme inhibition
  • Poly(ADP-ribose) glycohydrolase
  • Poly(ADP-ribosyl)ation
  • Structure-activity relationship
  • Tannin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Aoki, K., Nishimura, K., Abe, H., Maruta, H., Sakagami, H., Hatano, T., ... Tanuma, S. I. (1993). Novel inhibitors of poly(ADP-ribose) glycohydrolase. Biochimica et Biophysica Acta - General Subjects, 1158(3), 251-256. https://doi.org/10.1016/0304-4165(93)90022-Z

Novel inhibitors of poly(ADP-ribose) glycohydrolase. / Aoki, Kazuma; Nishimura, Koji; Abe, Hideaki; Maruta, Hideharu; Sakagami, Hiroshi; Hatano, Tsutomu; Okuda, Takuo; Yoshida, Takashi; Tsai, Yan Jyu; Uchiumi, Fumiaki; Tanuma, Sei ichi.

In: Biochimica et Biophysica Acta - General Subjects, Vol. 1158, No. 3, 28.11.1993, p. 251-256.

Research output: Contribution to journalArticle

Aoki, K, Nishimura, K, Abe, H, Maruta, H, Sakagami, H, Hatano, T, Okuda, T, Yoshida, T, Tsai, YJ, Uchiumi, F & Tanuma, SI 1993, 'Novel inhibitors of poly(ADP-ribose) glycohydrolase', Biochimica et Biophysica Acta - General Subjects, vol. 1158, no. 3, pp. 251-256. https://doi.org/10.1016/0304-4165(93)90022-Z
Aoki, Kazuma ; Nishimura, Koji ; Abe, Hideaki ; Maruta, Hideharu ; Sakagami, Hiroshi ; Hatano, Tsutomu ; Okuda, Takuo ; Yoshida, Takashi ; Tsai, Yan Jyu ; Uchiumi, Fumiaki ; Tanuma, Sei ichi. / Novel inhibitors of poly(ADP-ribose) glycohydrolase. In: Biochimica et Biophysica Acta - General Subjects. 1993 ; Vol. 1158, No. 3. pp. 251-256.
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