TY - JOUR
T1 - Novel inhibitors of poly(ADP-ribose) glycohydrolase
AU - Aoki, Kazuma
AU - Nishimura, Koji
AU - Abe, Hideaki
AU - Maruta, Hideharu
AU - Sakagami, Hiroshi
AU - Hatano, Tsutomu
AU - Okuda, Takuo
AU - Yoshida, Takashi
AU - Tsai, Yan Jyu
AU - Uchiumi, Fumiaki
AU - Tanuma, Sei ichi
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid from the Ministry of Education, Science and Culture of Japan.
PY - 1993/11/28
Y1 - 1993/11/28
N2 - The inhibitory effects on poly(ADP-ribose) glycohydrolase purified from human placenta of three classes of chemically defined tannins; gallotannins; ellagitannins and condensed tannins, were examined in vitro. Oligometric ellagitannins were found to be most potent inhibitors of poly(ADP-ribose) glycohydrolase, their potencies increasing with increasing number of monomeric residues (dinner < trimer < tetramer). Monomeric ellagitannins and gallotannins were less inhibitory. Condensed tannins, which consist of an epicatechin gallate oligomer without a glucose core, were not appreciably inhibitory. A structure-activity study showed that higher-order confirmations of the conjugates with glucose of hexahydroxydiphenoyl and valoneoyl groups, which are unique components of ellegitannins, cooperatively potentiated the inhibitory activity.
AB - The inhibitory effects on poly(ADP-ribose) glycohydrolase purified from human placenta of three classes of chemically defined tannins; gallotannins; ellagitannins and condensed tannins, were examined in vitro. Oligometric ellagitannins were found to be most potent inhibitors of poly(ADP-ribose) glycohydrolase, their potencies increasing with increasing number of monomeric residues (dinner < trimer < tetramer). Monomeric ellagitannins and gallotannins were less inhibitory. Condensed tannins, which consist of an epicatechin gallate oligomer without a glucose core, were not appreciably inhibitory. A structure-activity study showed that higher-order confirmations of the conjugates with glucose of hexahydroxydiphenoyl and valoneoyl groups, which are unique components of ellegitannins, cooperatively potentiated the inhibitory activity.
KW - Ellagitannin
KW - Enzyme inhibition
KW - Poly(ADP-ribose) glycohydrolase
KW - Poly(ADP-ribosyl)ation
KW - Structure-activity relationship
KW - Tannin
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U2 - 10.1016/0304-4165(93)90022-Z
DO - 10.1016/0304-4165(93)90022-Z
M3 - Article
C2 - 8251524
AN - SCOPUS:0027438480
SN - 0304-4165
VL - 1158
SP - 251
EP - 256
JO - Biochimica et Biophysica Acta - General Subjects
JF - Biochimica et Biophysica Acta - General Subjects
IS - 3
ER -