Novel imidazole derivatives with subtype-selective antimuscarinic activity

Hiroyuki Miyachi, Hiromi Kiyota, Mitsuru Segawa

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A series of 4-(2-methylimidazol-1-yl)-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. On the basis of measurements of the antimuscarinic activity and subtype- selectivity for M2 and M3 muscarinic receptors, the structure-activity relationships of these compounds are discussed.

Original languageEnglish
Pages (from-to)2163-2168
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number16
DOIs
Publication statusPublished - Aug 18 1998
Externally publishedYes

Fingerprint

Muscarinic Antagonists
4-methylimidazole
Muscarinic M3 Receptors
Muscarinic M2 Receptors
Derivatives
Structure-Activity Relationship
imidazole
2-methylimidazole

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Novel imidazole derivatives with subtype-selective antimuscarinic activity. / Miyachi, Hiroyuki; Kiyota, Hiromi; Segawa, Mitsuru.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 8, No. 16, 18.08.1998, p. 2163-2168.

Research output: Contribution to journalArticle

Miyachi, Hiroyuki ; Kiyota, Hiromi ; Segawa, Mitsuru. / Novel imidazole derivatives with subtype-selective antimuscarinic activity. In: Bioorganic and Medicinal Chemistry Letters. 1998 ; Vol. 8, No. 16. pp. 2163-2168.
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