Novel imidazole derivatives with subtype-selective antimuscarinic activity (1)

Hiroyuki Miyachi, Hiromi Kiyota, Mitsuru Segawa

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A series of N-substituted 4-amino-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. The representative compound KRP-197, bearing a 2-methylimidazole ring as a surrogate of aliphatic amine, was found to be a highly potent and both M1- and M3-selective antimuscarinic agent.

Original languageEnglish
Pages (from-to)1807-1812
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number14
DOIs
Publication statusPublished - Jul 21 1998
Externally publishedYes

Fingerprint

Muscarinic Antagonists
Bearings (structural)
Derivatives
Amines
imidazole
2-methylimidazole
imidafenacin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Novel imidazole derivatives with subtype-selective antimuscarinic activity (1). / Miyachi, Hiroyuki; Kiyota, Hiromi; Segawa, Mitsuru.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 8, No. 14, 21.07.1998, p. 1807-1812.

Research output: Contribution to journalArticle

Miyachi, Hiroyuki ; Kiyota, Hiromi ; Segawa, Mitsuru. / Novel imidazole derivatives with subtype-selective antimuscarinic activity (1). In: Bioorganic and Medicinal Chemistry Letters. 1998 ; Vol. 8, No. 14. pp. 1807-1812.
@article{6829a7b46de94f5f8b772428319730dd,
title = "Novel imidazole derivatives with subtype-selective antimuscarinic activity (1)",
abstract = "A series of N-substituted 4-amino-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. The representative compound KRP-197, bearing a 2-methylimidazole ring as a surrogate of aliphatic amine, was found to be a highly potent and both M1- and M3-selective antimuscarinic agent.",
author = "Hiroyuki Miyachi and Hiromi Kiyota and Mitsuru Segawa",
year = "1998",
month = "7",
day = "21",
doi = "10.1016/S0960-894X(98)00312-6",
language = "English",
volume = "8",
pages = "1807--1812",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "14",

}

TY - JOUR

T1 - Novel imidazole derivatives with subtype-selective antimuscarinic activity (1)

AU - Miyachi, Hiroyuki

AU - Kiyota, Hiromi

AU - Segawa, Mitsuru

PY - 1998/7/21

Y1 - 1998/7/21

N2 - A series of N-substituted 4-amino-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. The representative compound KRP-197, bearing a 2-methylimidazole ring as a surrogate of aliphatic amine, was found to be a highly potent and both M1- and M3-selective antimuscarinic agent.

AB - A series of N-substituted 4-amino-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. The representative compound KRP-197, bearing a 2-methylimidazole ring as a surrogate of aliphatic amine, was found to be a highly potent and both M1- and M3-selective antimuscarinic agent.

UR - http://www.scopus.com/inward/record.url?scp=0032555251&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032555251&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(98)00312-6

DO - 10.1016/S0960-894X(98)00312-6

M3 - Article

C2 - 9873438

AN - SCOPUS:0032555251

VL - 8

SP - 1807

EP - 1812

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 14

ER -