Novel imidazole derivatives with subtype-selective antimuscarinic activity (1)

Hiroyuki Miyachi, Hiromi Kiyota, Mitsuru Segawa

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

A series of N-substituted 4-amino-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. The representative compound KRP-197, bearing a 2-methylimidazole ring as a surrogate of aliphatic amine, was found to be a highly potent and both M1- and M3-selective antimuscarinic agent.

Original languageEnglish
Pages (from-to)1807-1812
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number14
DOIs
Publication statusPublished - Jul 21 1998

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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