Abstract
A series of N-substituted 4-amino-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. The representative compound KRP-197, bearing a 2-methylimidazole ring as a surrogate of aliphatic amine, was found to be a highly potent and both M1- and M3-selective antimuscarinic agent.
| Original language | English |
|---|---|
| Pages (from-to) | 1807-1812 |
| Number of pages | 6 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 8 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - Jul 21 1998 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Novel imidazole derivatives with subtype-selective antimuscarinic activity (1). / Miyachi, Hiroyuki; Kiyota, Hiromi; Segawa, Mitsuru.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 8, No. 14, 21.07.1998, p. 1807-1812.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Novel imidazole derivatives with subtype-selective antimuscarinic activity (1)
AU - Miyachi, Hiroyuki
AU - Kiyota, Hiromi
AU - Segawa, Mitsuru
PY - 1998/7/21
Y1 - 1998/7/21
N2 - A series of N-substituted 4-amino-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. The representative compound KRP-197, bearing a 2-methylimidazole ring as a surrogate of aliphatic amine, was found to be a highly potent and both M1- and M3-selective antimuscarinic agent.
AB - A series of N-substituted 4-amino-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. The representative compound KRP-197, bearing a 2-methylimidazole ring as a surrogate of aliphatic amine, was found to be a highly potent and both M1- and M3-selective antimuscarinic agent.
UR - http://www.scopus.com/inward/record.url?scp=0032555251&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032555251&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(98)00312-6
DO - 10.1016/S0960-894X(98)00312-6
M3 - Article
C2 - 9873438
AN - SCOPUS:0032555251
VL - 8
SP - 1807
EP - 1812
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 14
ER -