Novel imidazole derivatives with subtype-selective antimuscarinic activity (1)

Hiroyuki Miyachi; Hiromi Kiyota; Mitsuru Segawa

doi:10.1016/S0960-894X(98)00312-6

Novel imidazole derivatives with subtype-selective antimuscarinic activity (1)

Hiroyuki Miyachi, Hiromi Kiyota, Mitsuru Segawa

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

A series of N-substituted 4-amino-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. The representative compound KRP-197, bearing a 2-methylimidazole ring as a surrogate of aliphatic amine, was found to be a highly potent and both M₁- and M₃-selective antimuscarinic agent.

Original language	English
Pages (from-to)	1807-1812
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(98)00312-6
Publication status	Published - Jul 21 1998

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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AB - A series of N-substituted 4-amino-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. The representative compound KRP-197, bearing a 2-methylimidazole ring as a surrogate of aliphatic amine, was found to be a highly potent and both M1- and M3-selective antimuscarinic agent.

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Novel imidazole derivatives with subtype-selective antimuscarinic activity (1)

Abstract

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